Determination of the radioprotective effects of topical applications of MEA, WR-2721, and N-acetylcysteine on murine skin
Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 (S-2-(3-aminopropylamino)-ethylphosphorothioic acid), and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of /sup 137/Cs radiation. No significant protection was observed with either WR-2721 or NAC. MEA was shown to offer significant protection against acute skin damage in both buffered and unbuffered forms, but no significant protection against late contraction. The use of topical MEA on unanesthetized animals breathing carbogen (95% O2, 5% CO2) appears to give an enhanced level of radioprotection over that shown for anesthetized, air-breathing animals.
- Research Organization:
- Division of Radiation Biophysics, Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston
- OSTI ID:
- 5992161
- Journal Information:
- Radiat. Res.; (United States), Vol. 93:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
MEA
RADIOSENSITIVITY EFFECTS
SKIN
BIOLOGICAL RADIATION EFFECTS
CESIUM 137
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
MICE
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RADIOTHERAPY
ALKALI METAL ISOTOPES
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CESIUM ISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RODENTS
THERAPY
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)