Changes in distribution of hepatic blood flow induced by intra-arterial infusion of angiotensin II in human hepatic cancer

Journal Article · Tue Jan 15 00:00:00 EST 1985 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19850115)55:2<311::AID-CNCR2820550202>3.0.CO;2-M· OSTI ID:5982721

Sasaki, Y; Imaoka, S; Hasegawa, Y; Nakano, S; Ishikawa, O; Ohigashi, H; Taniguchi, K; Koyama, H; Iwanaga, T; Terasawa, T

Changes in the distribution of the hepatic blood flow induced by intra-arterial infusion of angiotensin II (AT-II) were studied in human hepatic cancers using extremely short-lived radioisotope (RI) (krypton 81 m (/sup 81m/Kr); half-life, 13 seconds). After the start of continuous infusion of AT-II, the radioactivity of the tumor showed about a two-fold increase, whereas that of the nontumor region decreased to about one half as much as the level before the infusion. Consequently, the mean ratio of the arterial blood flow in the tumor region to that in the nontumor region (T/N ratio) increased to 3.30 (P less than 0.001). The T/N ratio showed a peak before the peripheral blood pressure reached the maximum, and thereafter tended to decrease. Intra-arterial infusion of AT-II raised the T/N ratio more obviously than did intravenous infusion of the drug, with less rise in the peripheral blood pressure. It is believed that intra-arterial infusion chemotherapy with local use of AT-II enables better accessibility of chemotherapeutic drugs to tumors.

• Research Organization: Center for Adult Diseases, Osaka, Japan
• OSTI ID: 5982721
• Journal Information: Cancer (Philadelphia); (United States), Vol. 55:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
BIOLOGICAL EFFECTS
LIVER
BLOOD FLOW
ARTERIES
BLOOD PRESSURE
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
DYNAMIC FUNCTION STUDIES
HEPATOMAS
ISOMERIC NUCLEI
KRYPTON 81
LABELLED COMPOUNDS
RADIOACTIVITY
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
GLOBULINS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KRYPTON ISOTOPES
NEOPLASMS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THERAPY
VASOCONSTRICTORS
YEARS LIVING RADIOISOTOPES
550600* - Medicine
551001 - Physiological Systems- Tracer Techniques