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Title: Urinary trimethylselenonium excretion by the rat: effect of level and source of selenium-75

Abstract

The purpose of this study was to explore in rats the urinary metabolites of selenium (Se), by using (/sup 75/Se)selenomethionine, (/sup 75/Se)selenocystine, and (/sup 75/Se)selenite, and to assess the effects of low and high levels of Se intake on trimethylselenonium ion (TMSe) excretion in urine. Male adult rats were adapted for 6 weeks to a commercial rat laboratory stock diet (0.25 ppm Se). They were then starved for 24 hours and given an oral dose of either low (16 micrograms Se/kg body weight) or high (1500 micrograms Se/kg body weight) Se as the test Se compounds. Appearance of radioactivity in TMSe and non-TMSe Se metabolites in urine was monitored for 48 hours. About 40% of the /sup 75/Se dose was excreted in urine. TMSe was the major urinary Se metabolite at high, and a minor urinary Se metabolite at low dose levels of Se and for all three Se test compounds. At least 80% of urinary /sup 75/Se and 26-42% of the orally administered /sup 75/Se were excreted as non-TMSe Se metabolites in urine under the latter condition. It is hypothesized that at a requirement intake of Se either a trace or no TMSe is excreted in urine, and itmore » becomes a major excretory metabolite of Se when the dietary trace mineral intake exceeds a requirement level, probably serving as a means of detoxification.« less

Authors:
; ;
Publication Date:
Research Org.:
Massachusetts Inst. of Tech., Cambridge
OSTI Identifier:
5978918
Resource Type:
Journal Article
Journal Name:
J. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 113:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ORGANOMETALLIC COMPOUNDS; EXCRETION; METABOLITES; SELENIUM 75; TRACER TECHNIQUES; ORAL ADMINISTRATION; RATS; SELENIUM COMPOUNDS; URINE; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; RODENTS; SELENIUM ISOTOPES; VERTEBRATES; WASTES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Nahapetian, A T, Janghorbani, M, and Young, V R. Urinary trimethylselenonium excretion by the rat: effect of level and source of selenium-75. United States: N. p., 1983. Web.
Nahapetian, A T, Janghorbani, M, & Young, V R. Urinary trimethylselenonium excretion by the rat: effect of level and source of selenium-75. United States.
Nahapetian, A T, Janghorbani, M, and Young, V R. Tue . "Urinary trimethylselenonium excretion by the rat: effect of level and source of selenium-75". United States.
@article{osti_5978918,
title = {Urinary trimethylselenonium excretion by the rat: effect of level and source of selenium-75},
author = {Nahapetian, A T and Janghorbani, M and Young, V R},
abstractNote = {The purpose of this study was to explore in rats the urinary metabolites of selenium (Se), by using (/sup 75/Se)selenomethionine, (/sup 75/Se)selenocystine, and (/sup 75/Se)selenite, and to assess the effects of low and high levels of Se intake on trimethylselenonium ion (TMSe) excretion in urine. Male adult rats were adapted for 6 weeks to a commercial rat laboratory stock diet (0.25 ppm Se). They were then starved for 24 hours and given an oral dose of either low (16 micrograms Se/kg body weight) or high (1500 micrograms Se/kg body weight) Se as the test Se compounds. Appearance of radioactivity in TMSe and non-TMSe Se metabolites in urine was monitored for 48 hours. About 40% of the /sup 75/Se dose was excreted in urine. TMSe was the major urinary Se metabolite at high, and a minor urinary Se metabolite at low dose levels of Se and for all three Se test compounds. At least 80% of urinary /sup 75/Se and 26-42% of the orally administered /sup 75/Se were excreted as non-TMSe Se metabolites in urine under the latter condition. It is hypothesized that at a requirement intake of Se either a trace or no TMSe is excreted in urine, and it becomes a major excretory metabolite of Se when the dietary trace mineral intake exceeds a requirement level, probably serving as a means of detoxification.},
doi = {},
url = {https://www.osti.gov/biblio/5978918}, journal = {J. Nutr.; (United States)},
number = ,
volume = 113:2,
place = {United States},
year = {1983},
month = {2}
}