Increased weight loss in molybdenum-treated rats in the cold

Conference · Mon Jan 01 00:00:00 EST 1973 · Trace Subst. Environ. Health; (United States)

OSTI ID:5973915

Winston, P W; Hoffman, L; Smith, W

Excess dietary molybdenum appears to reduce the activity of copper, and the synthesis of both catecholamines and glucocorticoids requires copper. It is thus possible that elevated molybdenum would affect responses to stress. Rats were given Mo as Na/sub 2/MoO/sub 4/ in drinking water from birth at 10 ppM (A) and 0 ppM (N). All were 6-11 months old. Experimentals were kept at 2-3/sup 0/C for four days and controls kept at room temperature. Daily measurements were made of weight change and food consumption. For males weight loss in experimental A rats (12.9 +- 0.57%) was double experimental N's (7.7 +- 1.1%) and P < 0.01. For females weight loss in experimental A's (5.2 +- 0.48%) was more than triple experimental N's (1.4 +- 1.1%) and P < 0.1. In the controls males lost less than experimentals while females gained weight. A's and N's were the same within sexes. Results would indicate a lower stress response in females to the general experimental conditions and that elevated intake of molybdenum has a definite effect on response to cold even in animals long acclimated to the metal. 15 references, 1 figure, 2 tables.

• Research Organization: Univ. of Colorado, Boulder
• OSTI ID: 5973915
• Report Number(s): CONF-730613-
• Journal Information: Trace Subst. Environ. Health; (United States), Vol. 7; Conference: 7. annual conference on trace substances in environmental health, Columbia, MO, USA, 12 Jun 1973
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MOLYBDENUM
BIOLOGICAL EFFECTS
ANIMAL GROWTH
COPPER
INHIBITION
METABOLISM
RATS
ANIMALS
ELEMENTS
GROWTH
MAMMALS
METALS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)