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Title: Scurfy mice: A model for autoimmune disease

Abstract

Autoimmune disease-the condition in which the body attacks its own tissue-has been an object of public concern recently. Former President George Bush and his wife Barbara both are afflicted with Graves' disease in which the body's own immune system attakcs the thyroid gland. The safety of breast implants was called into question because of evidence that some recipients had developed autoimmune disorders such a rheumatoid arthritis, systemic lupus erythematosus, and scleroderma. Women, the media pointed out, have a higher-than-average incidence of many autoimmune disorders. These events suggest the need to know more about what makes the immune system work so well and what makes it go awry. At ORNL's Biology Division, progress is being in understanding the underlying causes of immune disease by studying mice having a disease that causes them to be underdeveloped; to have scaly skin, small ears, and large spleens; to open their eyes late; and to die early. These [open quotes]scurfy[close quotes]mice are helping us better understand the role of the thymus gland in autoimmune disease.

Authors:
Publication Date:
OSTI Identifier:
5953885
Alternate Identifier(s):
OSTI ID: 5953885
Resource Type:
Journal Article
Resource Relation:
Journal Name: Oak Ridge National Laboratory Review; (United States); Journal Volume: 26:1
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; MICE; IMMUNE SYSTEM DISEASES; IMMUNE REACTIONS; IMMUNITY; IMMUNOSUPPRESSION; LYMPHOCYTES; THYMUS; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; ORGANS; RODENTS; SOMATIC CELLS; VERTEBRATES 550400* -- Genetics; 550600 -- Medicine

Citation Formats

Godfrey, V.L. Scurfy mice: A model for autoimmune disease. United States: N. p., 1993. Web.
Godfrey, V.L. Scurfy mice: A model for autoimmune disease. United States.
Godfrey, V.L. Fri . "Scurfy mice: A model for autoimmune disease". United States.
@article{osti_5953885,
title = {Scurfy mice: A model for autoimmune disease},
author = {Godfrey, V.L.},
abstractNote = {Autoimmune disease-the condition in which the body attacks its own tissue-has been an object of public concern recently. Former President George Bush and his wife Barbara both are afflicted with Graves' disease in which the body's own immune system attakcs the thyroid gland. The safety of breast implants was called into question because of evidence that some recipients had developed autoimmune disorders such a rheumatoid arthritis, systemic lupus erythematosus, and scleroderma. Women, the media pointed out, have a higher-than-average incidence of many autoimmune disorders. These events suggest the need to know more about what makes the immune system work so well and what makes it go awry. At ORNL's Biology Division, progress is being in understanding the underlying causes of immune disease by studying mice having a disease that causes them to be underdeveloped; to have scaly skin, small ears, and large spleens; to open their eyes late; and to die early. These [open quotes]scurfy[close quotes]mice are helping us better understand the role of the thymus gland in autoimmune disease.},
doi = {},
journal = {Oak Ridge National Laboratory Review; (United States)},
number = ,
volume = 26:1,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1993},
month = {Fri Jan 01 00:00:00 EST 1993}
}