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Title: Pharmacokinetics of cefixime

Abstract

The serum protein binding of cefixime, was concentration-dependent. Below 30 mcg/mL, free-fractions (fu) of cefixime in dog serum were approximately 8%. As cefixime concentrations increased, concomitant increases in free-fraction were observed. At 328 mcg/mL almost half of the cefixime in serum was not bound. To examine the effect of this concentration-dependent binding on cefixime's pharmacokinetics, four dogs were administered 50 mg/kg of the carbon 14-labeled drug by the oral and intravenous routes. The absolute bioavailability of cefixime was 48.0 +/- 17% (mean +/- SD). Absorption of radioactivity was 51.9 +/- 18%. Cefixime's elimination was a function of its free-fraction in serum and reabsorption of filtered drug by the kidney.

Authors:
Publication Date:
Research Org.:
Saint John's Univ., Jamaica, NY (USA)
OSTI Identifier:
5942428
Alternate Identifier(s):
OSTI ID: 5942428
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph.D.)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; PROTEINS; BIOCHEMICAL REACTION KINETICS; CARBON 14 COMPOUNDS; DOGS; INTRAVENOUS INJECTION; ORAL ADMINISTRATION; TRACER TECHNIQUES; ANIMALS; INJECTION; INTAKE; ISOTOPE APPLICATIONS; KINETICS; LABELLED COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; REACTION KINETICS; VERTEBRATES 550201* -- Biochemistry-- Tracer Techniques

Citation Formats

Tonelli, A.P. Pharmacokinetics of cefixime. United States: N. p., 1987. Web.
Tonelli, A.P. Pharmacokinetics of cefixime. United States.
Tonelli, A.P. Thu . "Pharmacokinetics of cefixime". United States.
@article{osti_5942428,
title = {Pharmacokinetics of cefixime},
author = {Tonelli, A.P.},
abstractNote = {The serum protein binding of cefixime, was concentration-dependent. Below 30 mcg/mL, free-fractions (fu) of cefixime in dog serum were approximately 8%. As cefixime concentrations increased, concomitant increases in free-fraction were observed. At 328 mcg/mL almost half of the cefixime in serum was not bound. To examine the effect of this concentration-dependent binding on cefixime's pharmacokinetics, four dogs were administered 50 mg/kg of the carbon 14-labeled drug by the oral and intravenous routes. The absolute bioavailability of cefixime was 48.0 +/- 17% (mean +/- SD). Absorption of radioactivity was 51.9 +/- 18%. Cefixime's elimination was a function of its free-fraction in serum and reabsorption of filtered drug by the kidney.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}

Thesis/Dissertation:
Other availability
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