skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Thyrotoxic periodic paralysis

Abstract

A case of thyrotoxic periodic paralysis is reported in a Hispanic man with an unusual recurrence six weeks after radioactive iodine treatment. Thyrotoxic periodic paralysis has now been well characterized in the literature: it occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion, with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is establishing a euthyroid state. The pathophysiology is still controversial, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of Miami School of Medicine, FL
OSTI Identifier:
5942034
Resource Type:
Journal Article
Journal Name:
Am. J. Med.; (United States)
Additional Journal Information:
Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; SIDE EFFECTS; THYROID; BIOLOGICAL RADIATION EFFECTS; CALCIUM; CARCINOMAS; HISPANIC AMERICANS; HYPERTHYROIDISM; PATHOGENESIS; PATIENTS; POTASSIUM; ALKALI METALS; ALKALINE EARTH METALS; BIOLOGICAL EFFECTS; BODY; DISEASES; ELEMENTS; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; HUMAN POPULATIONS; MEDICINE; METALS; MINORITY GROUPS; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; POPULATIONS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)

Citation Formats

Ferreiro, J.E., Arguelles, D.J., and Rams, H. Jr. Thyrotoxic periodic paralysis. United States: N. p., 1986. Web. doi:10.1016/0002-9343(86)90067-7.
Ferreiro, J.E., Arguelles, D.J., & Rams, H. Jr. Thyrotoxic periodic paralysis. United States. doi:10.1016/0002-9343(86)90067-7.
Ferreiro, J.E., Arguelles, D.J., and Rams, H. Jr. Wed . "Thyrotoxic periodic paralysis". United States. doi:10.1016/0002-9343(86)90067-7.
@article{osti_5942034,
title = {Thyrotoxic periodic paralysis},
author = {Ferreiro, J.E. and Arguelles, D.J. and Rams, H. Jr.},
abstractNote = {A case of thyrotoxic periodic paralysis is reported in a Hispanic man with an unusual recurrence six weeks after radioactive iodine treatment. Thyrotoxic periodic paralysis has now been well characterized in the literature: it occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion, with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is establishing a euthyroid state. The pathophysiology is still controversial, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself.},
doi = {10.1016/0002-9343(86)90067-7},
journal = {Am. J. Med.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {1986},
month = {1}
}