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Title: Projected uptake and toxicity of selenium compounds from the environment

Abstract

Industrial workers and members of the general public may be exposed to selenium by inhalation of selenium in the workplace or atmosphere or by ingestion of selenium in food. A model has been developed to evaluate the potential uptake of selenium in body tissues by these two exposure routes. Rates were estimated for transport of selenium between five compartments including lung, gastrointestinal tract, blood, liver and other tissues. Results of model simulations were compared to published tissue distribution information obtained from single inhalation exposures of rats and dogs to radiolabeled selenium compounds at concentrations from 20 mg/m/sup 3/ to 20 ..mu../m/sup 3/ with initial body burdens of selenium ranging from 28 to 0.09 ..mu..g Se/kg body wt. The model was then modified to predict equilibrium organ concentrations of selenium in people after continual exposure to selenium in the air or in the diet. Daily intake levels of 100 ..mu../day and a fractional absorption value of 0.8 were used. With an air concentration of 1 ng Se/m/sup 3/, model predictions indicated that most of the total body selenium in people is likely to come from their diet because selenium in the urban atmosphere contributes a very small part of the totalmore » body selenium. However, continual inhalation of selenium at the threshold limit value (TLV; 200 ..mu..g/m/sup 3/) could contribute significantly to the total body burden of selenium. Levels of selenium predicted in lung, liver, and blood after inhalation of selenium at the TLV were 22,000, 1200, and 440 ng Se/g tissue. Predicted lung concentrations were near those that produced toxic effects in animals after ingestion of Se. 31 references, 1 figure, 4 tables.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Inhalation Toxicoloty Research Institute, Albuquerque, NM
OSTI Identifier:
5940989
DOE Contract Number:  
AC04-76EV01013
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 36
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SELENIUM; TOXICITY; UPTAKE; BIOLOGICAL MODELS; BLOOD; BODY BURDEN; DOGS; ECOLOGICAL CONCENTRATION; EXPERIMENTAL DATA; GASTROINTESTINAL TRACT; INGESTION; INHALATION; LIVER; LUNGS; MAXIMUM PERMISSIBLE EXPOSURE; RATS; TISSUE DISTRIBUTION; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; DATA; DIGESTIVE SYSTEM; DISTRIBUTION; ELEMENTS; GLANDS; INFORMATION; INTAKE; MAMMALS; MATERIALS; NUMERICAL DATA; ORGANS; RESPIRATORY SYSTEM; RODENTS; SAFETY STANDARDS; SEMIMETALS; STANDARDS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Medinsky, M A, Cuddihy, R G, Griffith, W C, Weissman, S H, and McClellan, R O. Projected uptake and toxicity of selenium compounds from the environment. United States: N. p., 1985. Web. doi:10.1016/0013-9351(85)90016-7.
Medinsky, M A, Cuddihy, R G, Griffith, W C, Weissman, S H, & McClellan, R O. Projected uptake and toxicity of selenium compounds from the environment. United States. https://doi.org/10.1016/0013-9351(85)90016-7
Medinsky, M A, Cuddihy, R G, Griffith, W C, Weissman, S H, and McClellan, R O. 1985. "Projected uptake and toxicity of selenium compounds from the environment". United States. https://doi.org/10.1016/0013-9351(85)90016-7.
@article{osti_5940989,
title = {Projected uptake and toxicity of selenium compounds from the environment},
author = {Medinsky, M A and Cuddihy, R G and Griffith, W C and Weissman, S H and McClellan, R O},
abstractNote = {Industrial workers and members of the general public may be exposed to selenium by inhalation of selenium in the workplace or atmosphere or by ingestion of selenium in food. A model has been developed to evaluate the potential uptake of selenium in body tissues by these two exposure routes. Rates were estimated for transport of selenium between five compartments including lung, gastrointestinal tract, blood, liver and other tissues. Results of model simulations were compared to published tissue distribution information obtained from single inhalation exposures of rats and dogs to radiolabeled selenium compounds at concentrations from 20 mg/m/sup 3/ to 20 ..mu../m/sup 3/ with initial body burdens of selenium ranging from 28 to 0.09 ..mu..g Se/kg body wt. The model was then modified to predict equilibrium organ concentrations of selenium in people after continual exposure to selenium in the air or in the diet. Daily intake levels of 100 ..mu../day and a fractional absorption value of 0.8 were used. With an air concentration of 1 ng Se/m/sup 3/, model predictions indicated that most of the total body selenium in people is likely to come from their diet because selenium in the urban atmosphere contributes a very small part of the total body selenium. However, continual inhalation of selenium at the threshold limit value (TLV; 200 ..mu..g/m/sup 3/) could contribute significantly to the total body burden of selenium. Levels of selenium predicted in lung, liver, and blood after inhalation of selenium at the TLV were 22,000, 1200, and 440 ng Se/g tissue. Predicted lung concentrations were near those that produced toxic effects in animals after ingestion of Se. 31 references, 1 figure, 4 tables.},
doi = {10.1016/0013-9351(85)90016-7},
url = {https://www.osti.gov/biblio/5940989}, journal = {Environ. Res.; (United States)},
number = ,
volume = 36,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}