An evaluation of /sup 99m/Tc-TMP as a myocardial imaging agent
Based on the recent report (JNM 25:P15,'84) that cationic /sup 99m/Tc-TMP localized well in animal myocardium, the authors evaluated it for possible clinical use. It was prepared by heating dry /sup 99m/TcO/sub 4/ with 50 mg of TMP in <0.5 ml of methanol or DMSO at 98/sup 0/C for 30'. This reaction also produced 6-10% of an anionic complex impurity (RPTLC, KC/sub 18/F plate, 2% dimethyl phosphite in methanol). This impurity and unreacted TMP were removed by passing the complex through 3x1cm BIOSIL A column and washing with saline. Carrier free /sup 99m/Tc-TMP was eluted with 0.5 ml ethanol, diluted with saline and injected intravenously to rats, rabbits, cats, dogs and rhesus monkey for gamma camera imaging. Excellent myocardial localization was seen in all animals. The quantitative myocardial uptake of /sup 99m/Tc-TMP in rats was comparable to that of /sup 201/Tl. A normal male volunteer was injected with 6.6 mCi of /sup 99m/Tc TMP and gamma camera images were obtained. By 24 hrs, 16% of the injected dose was recovered in the urine. The /sup 99m/Tc-TMP in plasma was not protein bound as determined by gel chromatography and electrophoresis. There seems to be a wide species difference between man and animals in the pharmacokinetics and localization of /sup 99m/Tc-TMP.
- Research Organization:
- Upstate Medical Center, Syracuse, NY
- OSTI ID:
- 5938898
- Report Number(s):
- CONF-850611-; TRN: 87-039273
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DMSO
DIAGNOSTIC USES
LABELLING
MYOCARDIUM
RADIONUCLIDE KINETICS
SCINTISCANNING
TECHNETIUM 99
TISSUE DISTRIBUTION
UPTAKE
BIOCHEMICAL REACTION KINETICS
CATS
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
DOGS
EVALUATION
EXCRETION
INTRAVENOUS INJECTION
MACACUS
MAN
RABBITS
RADIOPHARMACEUTICALS
RATS
RENAL CLEARANCE
THALLIUM 201
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONKEYS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
REACTION KINETICS
RODENTS
SECONDS LIVING RADIOISOTOPES
SULFOXIDES
SYNTHESIS
TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560162 - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man