Mortality experience of atomic bomb survivors, 1950--1974. Life span study report 8

Beebe, G W; Kato, H; Land, C E

Title: Mortality experience of atomic bomb survivors, 1950--1974. Life span study report 8 (in Japanese and English)

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Abstract

The entire 1950--1974 mortality experience has been re-analyzed with particular attention to these questions: (1) is radiation carcinogenesis the only important late effect from the standpoint of mortality; (2) is the carcinogenic effect a general one, affecting all tissues and histologic types; (3) are there reliable city differences from which relative biological effectiveness (RBE) estimates could be made; (4) are Nagasaki data numerous enough to permit any close examination of the functional form of the gamma dose-response curve for specific cancers; and (5) can further insight be gained into the role of age in 1945 at the time of the bomb (ATB) upon the carcinogenic effect of ionizing radiation. Mortality from diseases other than cancer is thus far unrelated to ionizing radiation. Carcinogenic effects generally are not proportional to spontaneous incidence. Evidence of radiation carcinogenesis is much stronger in Hiroshima than in Nagasaki. Absolute risks per rad are higher in Hiroshima where neutrons contribute substantially to the total dose. The leukemogenic effect seems still to be present, especially in those aged 20 to 34 ATB. Age ATB plays an important role in the carcinogenic effect. In general the absolute risk, averaged over the entire period, increases with age ATB. Formore »« less

Authors:: Beebe, G W; Kato, H; Land, C E

Publication Date:: Sat Jan 01 00:00:00 EST 1977

Research Org.:: Radiation Effects Research Foundation, Hiroshima (Japan); Radiation Effects Research Foundation, Nagasaki (Japan). Nagasaki Branch

OSTI Identifier:: 5931546

Report Number(s):: RERF-TR-1-77

DOE Contract Number:: EX-76-C-28-3161

Resource Type:: Technical Report

Country of Publication:: United States

Language:: Japanese and English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; 59 BASIC BIOLOGICAL SCIENCES; A-BOMB SURVIVORS; DELAYED RADIATION EFFECTS; CARCINOGENESIS; AGE DEPENDENCE; DOSE-RESPONSE RELATIONSHIPS; IONIZING RADIATIONS; LEUKEMOGENESIS; LEUKEMIA; RADIOINDUCTION; NEOPLASMS; EXPERIMENTAL DATA; HIROSHIMA; MORTALITY; NAGASAKI; RBE; TABLES; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DATA; DATA FORMS; DISEASES; HEMIC DISEASES; INFORMATION; JAPAN; NUMERICAL DATA; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; 560151* - Radiation Effects on Animals- Man; 450202 - Explosions & Explosives- Nuclear- Weaponry- (-1989); 550900 - Pathology

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                    Beebe, G W, Kato, H, and Land, C E. Mortality experience of atomic bomb survivors, 1950--1974. Life span study report 8.  United States: N. p., 1977. 
        Web.

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                    Beebe, G W, Kato, H, & Land, C E. Mortality experience of atomic bomb survivors, 1950--1974. Life span study report 8.  United States.

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                    Beebe, G W, Kato, H, and Land, C E. 1977.  
        "Mortality experience of atomic bomb survivors, 1950--1974. Life span study report 8".  United States.

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@article{osti_5931546,

  title        = {Mortality experience of atomic bomb survivors, 1950--1974. Life span study report 8},

  author       = {Beebe, G W and Kato, H and Land, C E},

  abstractNote = {The entire 1950--1974 mortality experience has been re-analyzed with particular attention to these questions: (1) is radiation carcinogenesis the only important late effect from the standpoint of mortality; (2) is the carcinogenic effect a general one, affecting all tissues and histologic types; (3) are there reliable city differences from which relative biological effectiveness (RBE) estimates could be made; (4) are Nagasaki data numerous enough to permit any close examination of the functional form of the gamma dose-response curve for specific cancers; and (5) can further insight be gained into the role of age in 1945 at the time of the bomb (ATB) upon the carcinogenic effect of ionizing radiation. Mortality from diseases other than cancer is thus far unrelated to ionizing radiation. Carcinogenic effects generally are not proportional to spontaneous incidence. Evidence of radiation carcinogenesis is much stronger in Hiroshima than in Nagasaki. Absolute risks per rad are higher in Hiroshima where neutrons contribute substantially to the total dose. The leukemogenic effect seems still to be present, especially in those aged 20 to 34 ATB. Age ATB plays an important role in the carcinogenic effect. In general the absolute risk, averaged over the entire period, increases with age ATB. For none of the specific types of cancer except leukemia in Hiroshima are the data numerous enough to permit confident statements to be made about the shape of the dose-response curve in the low-dose region. The leukemogenic effect that dominated any consideration of late mortality effects until recently has now been exceeded by the effect of radiation on forms of cancer other than leukemia. At the end of 1974 excess deaths numbered about 85 for leukemia and 100 for other forms of cancer among the 82,000 A-bomb survivors under study. (ERB)},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5931546},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Sat Jan 01 00:00:00 EST 1977},

  month        = {Sat Jan 01 00:00:00 EST 1977}

}

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