Myocardial blood flow estimated by synchronous, multislice, high-speed computed tomography

Journal Article · Wed Mar 01 00:00:00 EST 1989 · IEEE Trans. Med. Imag.; (United States)

DOI:https://doi.org/10.1109/42.20364· OSTI ID:5930777

Wang, T; Wu, X; Chung, N; Ritman, E L

Anesthetized dogs were scanned in the dynamic spatial reconstructor, a fast multislice computed tomographic scanner. In one group of eight dogs, four differently radiolabeled microspheres (15 /mu/m diameter) were injected into the left atrium, with each label corresponding to a different hemodynamic condition. The image data collected from this group of dogs were used to develop the algorithm for estimating regional myocardial perfusion from the CT image data. In an additional 11 dogs three differently radiolabelled microspheres were also injected during different hemodynamic conditions. The image data collected from this second group of dogs were used to prospectively evaluate the accuracy of the algorithm developed from data in the first group of dogs. In all dogs scans of 0.127 second duration were recorded for each cardiac cycle before, during, and after a bolus injection of 32 ml Iohexol into the aortic root. Dye dilution curves were generated from brightness values measured from images of 2 mm thick transaxial slices. In all dogs images were reconstructed at the phase of each cardiac cycle and were analyzed to obtain estimates of myocardial perfusion F/sub DSR/. After the scans were completed, the hearts were sectioned and microsphere-based estimates of myocardial perfusion (F/sub MS/) were obtained. In the group of eight dogs the resulting value was expressed in flow per gram of muscle within the sampled volume of myocardium so that F/sub DSR/ = 0.996 F/sub MS/ + 0.49, r = 0.972. A similar linear relationship was also demonstrated in four quadrants and three transmural layers. In the group of 11 dogs F/sub DSR/ = 0.98 F/sub MS/ + 0.16, r = 0.95. The contrast clearance data were also used to deduce the ratio of intramyocardial blood volume to total myocardial volume. At flows greater than 7 ml/g/min, this ratio exceeded 20 percent, and at 1 ml/g/min was approximately 7 percent.

• Research Organization: Dept. of Physiology and Biophysics, Mayo Medical School, Rochester, MN (US)
• OSTI ID: 5930777
• Journal Information: IEEE Trans. Med. Imag.; (United States), Vol. 8:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
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DIAGNOSTIC USES
MYOCARDIUM
BLOOD FLOW
COMPUTERIZED TOMOGRAPHY
ACCURACY
BIOPSY
CALCULATION METHODS
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DIAGNOSTIC TECHNIQUES
HEART
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MAMMALS
MATHEMATICAL LOGIC
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USES
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