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Title: Acute effects of carbon monoxide on cardiac electrical stability

Abstract

The objective of this project was to determine the effects of acute carbon monoxide exposure on cardiac electrical stability. To obtain a comprehensive assessment, diverse biological models were employed. These involved cardiac electrical testing in the normal and ischemic heart in anesthetized and conscious dogs. The experimental plan was designed both to examine the direct effects of carbon monoxide exposure on the myocardium and to evaluate possible indirect influences through alterations in platelet aggregability or changes in central nervous system activity in the conscious animal. Our results indicate that exposure to relatively high levels of carbon monoxide, leading to carboxyhemoglobin concentrations of up to 20 percent, is without significant effect on ventricular electrical stability. This appears to be the case in the acutely ischemic heart as well as in the normal heart. It is important to note that the total exposure period was in the range of 90 to 124 minutes. The possibility that longer periods of exposure or exacerbation from nicotine in cigarette smoke could have a deleterious effect cannot be excluded. We also examined whether or not alterations in platelet aggregability due to carbon monoxide exposure could be a predisposing factor for cardiac arrhythmias. A model involving partialmore » coronary artery stenosis was used to simulate the conditions under which platelet plugs could lead to myocardial ischemia and life-threatening arrhythmias. We found no changes either in the cycle frequency of coronary blood flow oscillations or in platelet aggregability during carbon monoxide exposure. Thus, carbon monoxide exposure does not appear to alter platelet aggregability or its effect on coronary blood flow during stenosis. In the final series of experiments, we examined the effects of carbon monoxide exposure in the conscious state.« less

Authors:
; ;  [1]
  1. (Georgetown Univ. Medical Center, Washington, DC (USA))
Publication Date:
OSTI Identifier:
5923189
Alternate Identifier(s):
OSTI ID: 5923189
Resource Type:
Journal Article
Resource Relation:
Journal Name: Research Report Health Effects Institue; (USA); Journal Volume: 35
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD PLATELETS; BLOOD COAGULATION; CARBON MONOXIDE; BIOLOGICAL EFFECTS; HEART; SENSITIVITY; BLOOD FLOW; CARBOXYHEMOGLOBIN; CARDIOVASCULAR DISEASES; DOGS; ELECTROCARDIOGRAMS; METABOLISM; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARBON COMPOUNDS; CARBON OXIDES; CARDIOVASCULAR SYSTEM; CHALCOGENIDES; DIAGRAMS; DISEASES; MAMMALS; MATERIALS; ORGANS; OXIDES; OXYGEN COMPOUNDS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Verrier, R.L., Mills, A.K., and Skornik, W.A. Acute effects of carbon monoxide on cardiac electrical stability. United States: N. p., 1990. Web.
Verrier, R.L., Mills, A.K., & Skornik, W.A. Acute effects of carbon monoxide on cardiac electrical stability. United States.
Verrier, R.L., Mills, A.K., and Skornik, W.A. Mon . "Acute effects of carbon monoxide on cardiac electrical stability". United States. doi:.
@article{osti_5923189,
title = {Acute effects of carbon monoxide on cardiac electrical stability},
author = {Verrier, R.L. and Mills, A.K. and Skornik, W.A.},
abstractNote = {The objective of this project was to determine the effects of acute carbon monoxide exposure on cardiac electrical stability. To obtain a comprehensive assessment, diverse biological models were employed. These involved cardiac electrical testing in the normal and ischemic heart in anesthetized and conscious dogs. The experimental plan was designed both to examine the direct effects of carbon monoxide exposure on the myocardium and to evaluate possible indirect influences through alterations in platelet aggregability or changes in central nervous system activity in the conscious animal. Our results indicate that exposure to relatively high levels of carbon monoxide, leading to carboxyhemoglobin concentrations of up to 20 percent, is without significant effect on ventricular electrical stability. This appears to be the case in the acutely ischemic heart as well as in the normal heart. It is important to note that the total exposure period was in the range of 90 to 124 minutes. The possibility that longer periods of exposure or exacerbation from nicotine in cigarette smoke could have a deleterious effect cannot be excluded. We also examined whether or not alterations in platelet aggregability due to carbon monoxide exposure could be a predisposing factor for cardiac arrhythmias. A model involving partial coronary artery stenosis was used to simulate the conditions under which platelet plugs could lead to myocardial ischemia and life-threatening arrhythmias. We found no changes either in the cycle frequency of coronary blood flow oscillations or in platelet aggregability during carbon monoxide exposure. Thus, carbon monoxide exposure does not appear to alter platelet aggregability or its effect on coronary blood flow during stenosis. In the final series of experiments, we examined the effects of carbon monoxide exposure in the conscious state.},
doi = {},
journal = {Research Report Health Effects Institue; (USA)},
number = ,
volume = 35,
place = {United States},
year = {Mon Oct 01 00:00:00 EDT 1990},
month = {Mon Oct 01 00:00:00 EDT 1990}
}