Neonatal susceptibility to MHV3 infection in mice. II. Role of natural effector marrow cells in transfer of resistance

Journal Article · Tue Jan 01 00:00:00 EST 1980 · J. Immunol.; (United States)

OSTI ID:5920157

Tardieu, M; H'ery, C; Dupuy, J M

Protection of newborn mice against MHV3 infection requires the transfer of several cell populations originating from adult syngeneic donors: adherent spleen cells, T lymphocytes, and a third population present in the nonadherent spleen cell fraction, in peritoneal exudates, and in bone marrow cells (M cells). M cells were found to be sensitive to short-term incubation at 37 degrees C and to preincubation with anti-bone marrow antiserum, mitomycin C, puromycin, and aggregated Ig, the latter suggesting the presence of Fc receptors. They were resistant to silica particles but were sensitive to irradiation with x-rays as well as with 89Strontium. Nonadherent spleen cells, however, behaved differently from M cells toward x-irradiation since they were radio-resistant, suggesting that M cells are precursors that require further differentiation or division to participate in MHV3 resistance. Effector M cells responsible for MHV3 resistance display, therefore, some similarities with natural killing cells. They might belong to a group of effector cells operative in regulatory processes or anti-tumor surveillance but also may be defense mechanisms against infectious diseases.

• Research Organization: INSERM, Bicetre, France
• OSTI ID: 5920157
• Journal Information: J. Immunol.; (United States), Vol. 124:1
• Country of Publication: United States
• Language: English

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