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Title: Ultrastructural reevaluation of lead-induced patholoy in the kidney

Abstract

The renal pathology of rats injected with daily doses of 10.0 mg/kg body wt lead acetate was studied. Animals were sacrificed after 4 weeks of treatment and the renal cortices were sampled for pathological evaluation. No significant morphological lesion was observed in the control animals injected with saline solution. Light-microscopic examination of the lead-treated animals showed degenerative and necrotic changes in the proximal tubules. Intranuclear inclusion bodies could also be observed. Extensive morphological changes were revealed by electron microscopy. The most prominent lesions were observed in the pars recta segment of proximal tubules. Accumulation of lysosomes, particularly at the apical portion of the cells, was observed. Some of these lyosomes attained giant sizes of 8-10 ..mu..m in diameter. Matrical swelling of mitochondria was also a frequent finding. Besides the typical intranuclear lead inclusion bodies, pseudonuclear inclusions derived from extensive invaginations of the nuclear envelope were also found. Edematous dilation of the intercellular interdigitational spaces giving rise to sieve-like structures within epithelial cells were a common finding. Splitting of the basement membrane to form microspherical particle-filled pockets was also a prominent change in proximal tubules. This report presents a detailed reevaluation of morphological lesions produced in the kidney by inorganic lead.more » The various toxicopathological changes produced by lead may be used as a model for future studies of renal toxicants.« less

Authors:
; ;
Publication Date:
Research Org.:
Univ. of Arkansas, Little Rock
OSTI Identifier:
5917773
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 26:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; KIDNEYS; PATHOLOGICAL CHANGES; LEAD; BIOLOGICAL EFFECTS; ELECTRON MICROSCOPY; LEAD COMPOUNDS; LYSOSOMES; MITOCHONDRIA; OPTICAL MICROSCOPY; PATHOLOGY; RATS; TOXICITY; ANIMALS; BODY; CELL CONSTITUENTS; ELEMENTS; MAMMALS; METALS; MICROSCOPY; ORGANOIDS; ORGANS; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Chang, L W, Wade, P R, and Lee, G W. Ultrastructural reevaluation of lead-induced patholoy in the kidney. United States: N. p., 1981. Web.
Chang, L W, Wade, P R, & Lee, G W. Ultrastructural reevaluation of lead-induced patholoy in the kidney. United States.
Chang, L W, Wade, P R, and Lee, G W. Thu . "Ultrastructural reevaluation of lead-induced patholoy in the kidney". United States.
@article{osti_5917773,
title = {Ultrastructural reevaluation of lead-induced patholoy in the kidney},
author = {Chang, L W and Wade, P R and Lee, G W},
abstractNote = {The renal pathology of rats injected with daily doses of 10.0 mg/kg body wt lead acetate was studied. Animals were sacrificed after 4 weeks of treatment and the renal cortices were sampled for pathological evaluation. No significant morphological lesion was observed in the control animals injected with saline solution. Light-microscopic examination of the lead-treated animals showed degenerative and necrotic changes in the proximal tubules. Intranuclear inclusion bodies could also be observed. Extensive morphological changes were revealed by electron microscopy. The most prominent lesions were observed in the pars recta segment of proximal tubules. Accumulation of lysosomes, particularly at the apical portion of the cells, was observed. Some of these lyosomes attained giant sizes of 8-10 ..mu..m in diameter. Matrical swelling of mitochondria was also a frequent finding. Besides the typical intranuclear lead inclusion bodies, pseudonuclear inclusions derived from extensive invaginations of the nuclear envelope were also found. Edematous dilation of the intercellular interdigitational spaces giving rise to sieve-like structures within epithelial cells were a common finding. Splitting of the basement membrane to form microspherical particle-filled pockets was also a prominent change in proximal tubules. This report presents a detailed reevaluation of morphological lesions produced in the kidney by inorganic lead. The various toxicopathological changes produced by lead may be used as a model for future studies of renal toxicants.},
doi = {},
journal = {Environ. Res.; (United States)},
number = ,
volume = 26:1,
place = {United States},
year = {1981},
month = {10}
}