Target cells and thymus microenvironment in the pathogenesis of thymic lymphomas in C57BL/Ka mice
In C57BL/Ka mice, the induction of thymic lymphomas either by inoculation of radiation leukemia virus (RadLV) or by a split dose irradiation requires complex cellular events: 1) Target cells are found among the population of thymic subcapsular blast cells, or, alternatively, of marrow or spleen prothymocytes; 2) Progression of target cells to lymphoma growth requires a multi-step process, which occurs only within thymic microenvironment; 3) Target cells are rapidly induced as preleukemic cells; 4) After inoculation or RadLV, the initial events occur when target cells are in close association with cells of a specialized component of thymic epithelium, i.e., the so-called nurse cells; 5) The leukemogenic agents induce damages to the thymic microenvironment itself; 6) Lymphoma prevention by marrow grafting after irradiation results from mechanisms still unknown which inhibit the progression of preleukemic cells to neoplastic growth.
- Research Organization:
- State Univ. of Liege, Belgium
- OSTI ID:
- 5904886
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:1
- Country of Publication:
- United States
- Language:
- English
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LYMPHOMAS
PATHOGENESIS
RADIOINDUCTION
THYMUS
BIOLOGICAL RADIATION EFFECTS
BONE MARROW CELLS
LEUKEMIA VIRUSES
MICE
SPLEEN CELLS
WHOLE-BODY IRRADIATION
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MICROORGANISMS
NEOPLASMS
ONCOGENIC VIRUSES
ORGANS
PARASITES
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRUSES
560152* - Radiation Effects on Animals- Animals