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Title: Dissolution of metal tritides in a simulated lung fluid

Abstract

Metal tritides including titanium tritide (Ti {sup 3}H{sub x}) and erbium tritide (Er {sup 3}H{sub x}) have been used as components of neutron generators. The current understanding of metal tritides and their radiation dosimetry for internal exposure is very limited, and the ICRP Publication 30 does not provide for tritium dosimetry in metal tritide form. However, a few papers in the literature suggest that the solubility of metal tritides could be low. The current radiation protection guidelines for metal tritide particles are based on the assumption that their biological behavior is similar to tritiated water, which could be easily absorbed into body fluid. Therefore, these particles could have relatively short biological half-lives (10 d). If the solubility is low, the biological half-life of metal tritide particles and the dosimetry of an inhalation exposure to these particles could be quite different from tritiated water. This paper describes experiments on the dissolution rate of titanium tritide particles in a simulated lung fluid. Titanium tritide particles with mean sizes of 103 {mu}m (coarse) and 0.95 {mu}m (fine) were used. The results showed that the coarse particles dissolved much more slowly than the fine particles. The long-term dissolution half times were 361 and 33more » d for the coarse and fine particles, respectively. Dissolution data of the fine particles were consistent with the diffusion theory. The dissolution half times were longer than the 10-d biological half time for tritiated water in the body. This finding has significant implications for the current health protection guidelines, including annual limits of intakes and derived air concentrations.« less

Authors:
;  [1];  [2]
  1. Lovelace Respiratory Research Institute, Albuquerque, NM (United States)
  2. Sandia National Labs., Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Laboratory
Sponsoring Org.:
USDOE
OSTI Identifier:
589105
DOE Contract Number:  
AC04-94AL85000; AC04-76EV01013
Resource Type:
Journal Article
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 73; Journal Issue: 4; Other Information: PBD: Oct 1997
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; BIOLOGICAL HALF-LIFE; DISSOLUTION; ERBIUM COMPOUNDS; INHALATION; NEUTRON GENERATORS; RADIATION PROTECTION; SOLUBILITY; TITANIUM COMPOUNDS; TRITIDES; LUNGS

Citation Formats

Cheng, Yung-Sung, Dahl, A.R., and Jow, Hong Nian. Dissolution of metal tritides in a simulated lung fluid. United States: N. p., 1997. Web. doi:10.1097/00004032-199710000-00007.
Cheng, Yung-Sung, Dahl, A.R., & Jow, Hong Nian. Dissolution of metal tritides in a simulated lung fluid. United States. doi:10.1097/00004032-199710000-00007.
Cheng, Yung-Sung, Dahl, A.R., and Jow, Hong Nian. Wed . "Dissolution of metal tritides in a simulated lung fluid". United States. doi:10.1097/00004032-199710000-00007.
@article{osti_589105,
title = {Dissolution of metal tritides in a simulated lung fluid},
author = {Cheng, Yung-Sung and Dahl, A.R. and Jow, Hong Nian},
abstractNote = {Metal tritides including titanium tritide (Ti {sup 3}H{sub x}) and erbium tritide (Er {sup 3}H{sub x}) have been used as components of neutron generators. The current understanding of metal tritides and their radiation dosimetry for internal exposure is very limited, and the ICRP Publication 30 does not provide for tritium dosimetry in metal tritide form. However, a few papers in the literature suggest that the solubility of metal tritides could be low. The current radiation protection guidelines for metal tritide particles are based on the assumption that their biological behavior is similar to tritiated water, which could be easily absorbed into body fluid. Therefore, these particles could have relatively short biological half-lives (10 d). If the solubility is low, the biological half-life of metal tritide particles and the dosimetry of an inhalation exposure to these particles could be quite different from tritiated water. This paper describes experiments on the dissolution rate of titanium tritide particles in a simulated lung fluid. Titanium tritide particles with mean sizes of 103 {mu}m (coarse) and 0.95 {mu}m (fine) were used. The results showed that the coarse particles dissolved much more slowly than the fine particles. The long-term dissolution half times were 361 and 33 d for the coarse and fine particles, respectively. Dissolution data of the fine particles were consistent with the diffusion theory. The dissolution half times were longer than the 10-d biological half time for tritiated water in the body. This finding has significant implications for the current health protection guidelines, including annual limits of intakes and derived air concentrations.},
doi = {10.1097/00004032-199710000-00007},
journal = {Health Physics},
number = 4,
volume = 73,
place = {United States},
year = {1997},
month = {10}
}