Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents

Patent · Tue Nov 17 00:00:00 EST 1987

OSTI ID:5889877

Jones, A G; Davison, A; Abrams, M J

A method is described for preparing a coordination complex of an isonitrile ligand and a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta. The method comprises preparing a soluble metal adduct of the isonitrile ligand by admixing the ligand with a salt of a displaceable metal having a complete d-electron shell selected from the class consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing the metal isonitrile salt with a salt comprising the radioactive metal in a suitable solvent to displace the displaceable metal with the radioactive metal thereby forming the coordination complex.

• Assignee: President and Fellows of Harvard College and Massachusetts Institute of Technology, Cambridge, MA
• Patent Number(s): US 4707544
• OSTI ID: 5889877
• Resource Relation: Patent File Date: Filed date 28 Nov 1984
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
LABELLED COMPOUNDS
CHEMICAL COMPOSITION
CHEMICAL PREPARATION
ADDUCTS
BISMUTH COMPLEXES
CADMIUM COMPLEXES
CHROMIUM ISOTOPES
COBALT ISOTOPES
GALLIUM ISOTOPES
IMAGE PROCESSING
INDIUM COMPLEXES
IRIDIUM ISOTOPES
IRON ISOTOPES
ISONITRILES
LEAD COMPLEXES
LIGANDS
MANGANESE ISOTOPES
MERCURY COMPLEXES
MOLYBDENUM ISOTOPES
NICKEL ISOTOPES
NIOBIUM ISOTOPES
OSMIUM ISOTOPES
PALLADIUM ISOTOPES
PLATINUM ISOTOPES
RADIOISOTOPES
RHENIUM ISOTOPES
RUTHENIUM ISOTOPES
TANTALUM ISOTOPES
TECHNETIUM ISOTOPES
TELLURIUM COMPLEXES
TIN COMPLEXES
TUNGSTEN ISOTOPES
ZINC COMPLEXES
CARBONIC ACID DERIVATIVES
COMPLEXES
ISOTOPES
ORGANIC COMPOUNDS
PROCESSING
SYNTHESIS
400201* - Chemical & Physicochemical Properties