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Title: Renal brush-border Na/sup +/-H/sup +/ exchange activity in the aging rat

Abstract

Amiloride-sensitive Na/sup +/-H/sup +/ exchange activity in brush-border membrane vesicles isolated from male rat proximal tubules was decreased in the senescent rat (24 mo) compared with the young adult (6 mo). There was no significant loss in Na/sup +/-H/sup +/ exchange activity in the kidneys of animals between 6 and 18 mo of age. Amiloride-insensitive /sup 22/Na/sup +/ uptake and the rate of pH gradient dissipation were not altered during aging. The decrease in sodium-dependent (/sup 32/P) phosphate transport preceded the decline in Na/sup +/-H/sup +/ exchange activity by at least 6 mo. Sodium-dependent D-(/sup 3/H) glucose transport was not significantly altered during aging. Thus various renal plasma membrane transport functions were affected differently in the aging rat. The decrease in Na/sup +/-H/sup +/ exchange activity during aging contrasted with the increase in exchange activity reported previously in acute ablation models of chronic renal failure.

Authors:
;
Publication Date:
Research Org.:
National Institutes of Health Gerontology Research Center, Baltimore, MD
OSTI Identifier:
5879248
Resource Type:
Journal Article
Journal Name:
Am. J. Physiol.; (United States)
Additional Journal Information:
Journal Volume: 252:4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CATIONS; UPTAKE; LABELLED COMPOUNDS; MEMBRANE TRANSPORT; AGE DEPENDENCE; CELL MEMBRANES; GLUCOSE; KIDNEYS; MALES; PH VALUE; PHOSPHORUS 32; PROTONS; RATS; SODIUM 22; SODIUM COMPOUNDS; TRITIUM COMPOUNDS; ALDEHYDES; ALKALI METAL COMPOUNDS; ALKALI METAL ISOTOPES; ANIMALS; BARYONS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CELL CONSTITUENTS; CHARGED PARTICLES; DAYS LIVING RADIOISOTOPES; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HEXOSES; IONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEMBRANES; MONOSACCHARIDES; NUCLEI; NUCLEONS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHOSPHORUS ISOTOPES; RADIOISOTOPES; RODENTS; SACCHARIDES; SODIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Kinsella, J L, and Sacktor, B. Renal brush-border Na/sup +/-H/sup +/ exchange activity in the aging rat. United States: N. p., 1987. Web.
Kinsella, J L, & Sacktor, B. Renal brush-border Na/sup +/-H/sup +/ exchange activity in the aging rat. United States.
Kinsella, J L, and Sacktor, B. 1987. "Renal brush-border Na/sup +/-H/sup +/ exchange activity in the aging rat". United States.
@article{osti_5879248,
title = {Renal brush-border Na/sup +/-H/sup +/ exchange activity in the aging rat},
author = {Kinsella, J L and Sacktor, B},
abstractNote = {Amiloride-sensitive Na/sup +/-H/sup +/ exchange activity in brush-border membrane vesicles isolated from male rat proximal tubules was decreased in the senescent rat (24 mo) compared with the young adult (6 mo). There was no significant loss in Na/sup +/-H/sup +/ exchange activity in the kidneys of animals between 6 and 18 mo of age. Amiloride-insensitive /sup 22/Na/sup +/ uptake and the rate of pH gradient dissipation were not altered during aging. The decrease in sodium-dependent (/sup 32/P) phosphate transport preceded the decline in Na/sup +/-H/sup +/ exchange activity by at least 6 mo. Sodium-dependent D-(/sup 3/H) glucose transport was not significantly altered during aging. Thus various renal plasma membrane transport functions were affected differently in the aging rat. The decrease in Na/sup +/-H/sup +/ exchange activity during aging contrasted with the increase in exchange activity reported previously in acute ablation models of chronic renal failure.},
doi = {},
url = {https://www.osti.gov/biblio/5879248}, journal = {Am. J. Physiol.; (United States)},
number = ,
volume = 252:4,
place = {United States},
year = {Wed Apr 01 00:00:00 EST 1987},
month = {Wed Apr 01 00:00:00 EST 1987}
}