Validation of binding of SE-75 labeled sucralfate to sites of gastrointestinal ulceration
This study was performed to determine if and for how long sucralfate (SU) binds selectively to sites of gastro-intestinal (GI) ulceration. Se-Su was prepared by sulfating sucrose with tracer Se-75 and precipitating it as the basic Al salt. All patients (pts) had endoscopy to confirm the presence of either: esophagitis (n=5), gastritis (GA) (n=5), gastric ulcers (GU) (n=5), duodenal ulcers (DU) (n=5), or no ulceration (NU) (n=5). Following an overnight fast the pts swallowed 1 gm with 100 ..mu..Ci of Se-SU and were imaged continuously over 24 hours or until no activity remained in the upper GI tract. Pts with GU visually demonstrated focal SU binding at the ulcers for an average of 3.9 +- 1.1 hrs. with a mean GET of 68 +- 25 min. Mean GET for pts with DU was prolonged, 171 +- 63 min, however focal binding at duodenal ulcers was not seen. All pts with GA had diffuse retention of SU in the stomach with a mean GET of 118 +- 34 min. Focal binding of SU at all sites of esophagitis was seen with a T-1/2 of 65 +- 32 min at the ulcerations. In conclusion these data support the theory that the mechanism of ulcer healing with SU is related to its ability to adhere to the ulcer site forming a protective barrier. In addition Se-SU is a potential ulcer imaging agent which can be used to noninvasively assess healing.
- Research Organization:
- Temple Univ. Health Sciences Center, Philadelphia, PA
- OSTI ID:
- 5872204
- Report Number(s):
- CONF-850611-; TRN: 87-039628
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
GASTROINTESTINAL TRACT
RADIONUCLIDE KINETICS
SACCHAROSE
THERAPEUTIC USES
SELENIUM 75
DIAGNOSTIC USES
TISSUE DISTRIBUTION
ULCERS
HEALING
THERAPY
ALUMINIUM SULFATES
CHEMICAL PREPARATION
DYNAMIC FUNCTION STUDIES
LABELLING
ORAL ADMINISTRATION
RADIOPHARMACEUTICALS
RADIOTHERAPY
RETENTION FUNCTIONS
SCINTISCANNING
STOMACH
UPTAKE
ALUMINIUM COMPOUNDS
BETA DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BODY
CARBOHYDRATES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISACCHARIDES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RECOVERY
SACCHARIDES
SELENIUM ISOTOPES
SULFATES
SULFUR COMPOUNDS
SYNTHESIS
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques