Nuclear Medicine Program progress report for quarter ending September 30, 1991
Rat tissue distribution properties of IQNP,'' a new radioiodinated cholinergic-muscarinic receptor antagonist, are described. IQNP is the acronym for 1-azabicyclo(2.2.2)oct-3-yl {alpha}-hydroxy-{alpha}-phenyl-{alpha}(1-iodo-1-propen-3-yl) acetate, which is an analogue of the QNB muscarinic antagonist in which the p-iodophenyl moiety has been replaced with the 1-iodo-1-propen-3-yl moiety. The radioiodinated IQNP analogue is easier to prepare in much higher yields than QNB and is thus a candidate for the evaluation of muscarinic receptors by external imaging techniques. Studies in rats demonstrated that IQNP shows high uptake in those cerebral regions rich in muscarinic receptors QNB-treatment of rats either 1 h before (pre) or 2 h after (post) administration of radioiodinated IQNP resulted in significant displacement or blocking of cerebral specific IQNP uptake (% dose/gm) in the cortex and striatum. These studies demonstrate that IQNP has specificity for the cholinergic-muscarinic receptor and is a good candidate for further studies. Also during this period, several agents developed in the ORNL Nuclear Medicine Program were supplied to Medical Cooperative Programs for collaborative studies including the iodine-125-labeled BMIPP and DMIPP fatty acid analogues and the IPM antibody labeling agent. Tin-117m and gold-199 were produced in the ORNL High Flux Isotope Reactor (HFIR) and supplied to the OHER-supported program in the Medical Department at Brookhaven National Laboratory to aid in their research until the re-start of the High Flux Brookhaven Reactor.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5865129
- Report Number(s):
- ORNL/TM-11992; ON: DE92006979
- Country of Publication:
- United States
- Language:
- English
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Nuclear medicine program progress report for quarter ending December 31, 1992
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59 BASIC BIOLOGICAL SCIENCES
ACETATES
TISSUE DISTRIBUTION
LABELLED COMPOUNDS
NUCLEAR MEDICINE
RESEARCH PROGRAMS
ACETYLCHOLINE
ANIMAL TISSUES
CEREBELLUM
CEREBRAL CORTEX
CHEMICAL BONDS
GOLD 199
IODINATION
IODINE 125
LIGANDS
PROGRESS REPORT
RATS
TIN 117
UPTAKE
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
GOLD ISOTOPES
HALOGENATION
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
RADIOISOTOPES
RODENTS
STABLE ISOTOPES
TIN ISOTOPES
TISSUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550201 - Biochemistry- Tracer Techniques