Role of zinc, copper and cadmium in the regulation of aryl sulfotransferase IV activity in rat liver

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5863430

Chung, K; Howell, B; Norton, T; Ringer, D ^[1]

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1. The Noble Foundation, Ardmore, OK (United States)

Purified rat liver aryl sulfotransferase IV (AST IV) was found to be inhibited in vitro by Zn, Cu, Cd and Tb. Cu, Zn and Cd were all strongly inhibitory at very low concentrations. Cu, Zn and Cd at 2.5{mu}M to 0.025{mu}M could decrease the enzyme activity to {le} 50% Tb also showed a slight inhibitory effect on AST IV activity. In rat liver cytosols, Zn, Cu and Cd at 25{mu}M to .25{mu}M also decreased sulfotransferase activity to {le} 50% of controls. In order to asses the possible effects of these metals in vivo on liver AST IV activity, studies of increased dietary exposure to Zn, Cu and Cd were conducted. Male Sprague-Dawley rats were fed one of twelve diets varied in Zn, Cu and Cd content. The effect of chronic high, Cu and Cd ingestion and short term Zn administration were examined. In the chronic experiment, Cu deficiency resulted in reduction in liver Cu, and high Cu resulted in higher accumulation in liver Cu, but Zn content in diet had less effect in reduction or accumulation in liver tissue Zn. AST IV activity was only slightly decreased or normal by the chronic ingestion of Zn, Cu and Cd. The acute administration of Zn caused a slight decrease of liver AST IV activity.

• OSTI ID: 5863430
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
METABOLISM
COPPER
TERBIUM
TRANSFERASES
ENZYME ACTIVITY
ZINC
INHIBITION
LIVER
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
ELEMENTS
ENZYMES
GLANDS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RARE EARTHS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology