Intravenous elimination and percutaneous absorption of topically applied guanazole-14C (NSC-1895) in Yorkshire white pigs. Final report, 2 August 1976-7 December 1977

Technical Report · Wed Mar 01 00:00:00 EST 1978

OSTI ID:5843538

Skierkowski, P; Murphy, J C; Watson, E S; Folk, R M; Pavkov, K L

The elimination of intravenously administered Guanazole-14C was studied in female, weanling, Yorkshire white pigs to determine the total percentage of such a dose eliminated in the urine. Ninety-six percent of the dose was eliminated after 72 hours. This elimination percentage was then utilized to determine the amount of Guanazole-14C absorbed after topical application of the drug. After 48 hours, approximately 0.2% of the topically applied dose was absorbed through the skin of the test animals. Most tissue levels were not significant. However, adrenals and ovaries, although small, showed high specific activity levels of radioactivity. Bone samples after 24 hours also showed significant uptake. A significant percentage of the applied dose was generally detected at and around the site of application.

• Research Organization: Battelle Columbus Toxicology Program Office, McLean, VA (USA); Mississippi Univ., University (USA). Research Inst. of Pharmaceutical Sciences
• DOE Contract Number: N01-CM-4-3746
• OSTI ID: 5843538
• Report Number(s): PB-290430; TRN: 80-001332
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
SKIN ABSORPTION
TISSUE DISTRIBUTION
CARBON 14 COMPOUNDS
EXCRETION
INTRAVENOUS INJECTION
SWINE
TRACER TECHNIQUES
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DISTRIBUTION
DOMESTIC ANIMALS
DRUGS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
UPTAKE
VERTEBRATES
WASTES
551001* - Physiological Systems- Tracer Techniques
550600 - Medicine