Intestinal transport of zinc and folic acid: a mutual inhibitory effect
Recent observations suggest an inverse relationship between folic acid intake and zinc nutriture and indicate an interaction between folic acid and zinc at the intestinal level. To define that interaction, we designed in vivo and in vitro transport studies in which folic acid transport in the presence of zinc, as well as zinc transport in the presence of folic acid was examined. These studies show that zinc transport is significantly decreased when folate is present in the intestinal lumen. Similarly folic acid transport is significantly decreased with the presence of zinc. To determine whether this intestinal inhibition is secondary to zinc and folate-forming complexes, charcoal-binding studies were performed. These studies indicate that zinc and folate from complexes at pH 2.0, but that at pH 6.0, these complexes dissolve. Therefore, our studies suggest that under normal physiological conditions a mutual inhibition between folate and zinc exists at the site of intestinal transport.
- Research Organization:
- Vanderbilt Univ. Medical Center, Nashville, TN
- OSTI ID:
- 5842821
- Journal Information:
- Am. J. Clin. Nutr.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FOLIC ACID
INTESTINAL ABSORPTION
ZINC
BIOLOGICAL EFFECTS
CHARCOAL
IN VITRO
IN VIVO
RATS
ABSORPTION
ADSORBENTS
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
CARBOXYLIC ACIDS
DRUGS
ELEMENTS
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PTERIDINES
RODENTS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)