ACTH and. cap alpha. -melanotropin in central temperature control

Lipton, J M; Glyn, J R; Zimmer, J A

Title: ACTH and. cap alpha. -melanotropin in central temperature control

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Abstract

Adrenocorticotropin (ACTH) and ..cap alpha..-melanotropin (..cap alpha..-MSH) occur in brain tissue known to be important to temperature control. These peptides cause hypothermia if they are injected centrally in sufficient doses, but they do not act on the central set point of temperature control. Instead they appear to inhibit central pathways for heat conservation and production. In addition to their hypothermic capability, these peptides are antipyretic when given centrally in doses that have no effect on normal body temperature. ACTH has previously been associated with fever reduction in both clinical and experimental studies, and it may be that endogenous central ACTH is important for limitation of maximal fever. The hypothermic and antipyretic effects of ACTH do not depend on stimulation of the adrenal cortex because they are also observed in adrenalectomized rabbits. Nor is the antipyretic effect limited to the rabbit inasmuch as a comparable effect has been demonstrated in the squirrel monkey. The two peptides may be involved in central mediation of normal thermoregulation and fever, perhaps limiting the febrile response and other rises in body temperature by acting as neurotransmitters or neuromodulators in central thermoregulatory pathways.

Authors:: Lipton, J M; Glyn, J R; Zimmer, J A

Publication Date:: Sun Nov 01 00:00:00 EST 1981

Research Org.:: Univ. of Texas Health Science Center, Dallas

OSTI Identifier:: 5841521

Resource Type:: Journal Article

Journal Name:: Fed. Proc.; (United States)

Additional Journal Information:: Journal Volume: 40:13; Conference: Newer putative central neurotransmitters: roles in thermoregulation, Atlanta, GA, USA, 14 Apr 1981

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NEUROREGULATORS; BIOCHEMICAL REACTION KINETICS; THERMOREGULATION; BIOLOGICAL PATHWAYS; ACTH; ANTIPYRETICS; DYNAMIC FUNCTION STUDIES; EXPERIMENTAL DATA; HYPOTHALAMUS; NERVE CELLS; PEPTIDES; RABBITS; ANIMAL CELLS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONTROL; DATA; DRUGS; HORMONES; INFORMATION; KINETICS; MAMMALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; REACTION KINETICS; SOMATIC CELLS; TEMPERATURE CONTROL; VERTEBRATES; 560205* - Thermal Effects- Vertebrates- (-1987); 550100 - Behavioral Biology

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                    Lipton, J M, Glyn, J R, and Zimmer, J A. ACTH and. cap alpha. -melanotropin in central temperature control.  United States: N. p., 1981. 
        Web.

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                    Lipton, J M, Glyn, J R, & Zimmer, J A. ACTH and. cap alpha. -melanotropin in central temperature control.  United States.

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                    Lipton, J M, Glyn, J R, and Zimmer, J A. 1981.  
        "ACTH and. cap alpha. -melanotropin in central temperature control".  United States.

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@article{osti_5841521,

  title        = {ACTH and. cap alpha. -melanotropin in central temperature control},

  author       = {Lipton, J M and Glyn, J R and Zimmer, J A},

  abstractNote = {Adrenocorticotropin (ACTH) and ..cap alpha..-melanotropin (..cap alpha..-MSH) occur in brain tissue known to be important to temperature control. These peptides cause hypothermia if they are injected centrally in sufficient doses, but they do not act on the central set point of temperature control. Instead they appear to inhibit central pathways for heat conservation and production. In addition to their hypothermic capability, these peptides are antipyretic when given centrally in doses that have no effect on normal body temperature. ACTH has previously been associated with fever reduction in both clinical and experimental studies, and it may be that endogenous central ACTH is important for limitation of maximal fever. The hypothermic and antipyretic effects of ACTH do not depend on stimulation of the adrenal cortex because they are also observed in adrenalectomized rabbits. Nor is the antipyretic effect limited to the rabbit inasmuch as a comparable effect has been demonstrated in the squirrel monkey. The two peptides may be involved in central mediation of normal thermoregulation and fever, perhaps limiting the febrile response and other rises in body temperature by acting as neurotransmitters or neuromodulators in central thermoregulatory pathways.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5841521},
  journal      = {Fed. Proc.; (United States)},
number       = ,

  volume       = 40:13,

  place        = {United States},

  year         = {Sun Nov 01 00:00:00 EST 1981},

  month        = {Sun Nov 01 00:00:00 EST 1981}

}

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