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Title: Ethanol intake and sup 3 H-serotonin uptake I: A study in Fawn-Hooded rats

Abstract

Ethanol intake and synaptosomal {sup 3}H-serotonin uptake were studied in male Fawn-Hooded and Sprague-Dawley rats. Fawn-Hooded rats consumed more alcohol and more water than Sprague-Dawley rats. Plasma alcohol levels of Sprague-Dawley rats were not detectable but were about 5 mg/dl in Fawn-Hooded rats. Ethanol intake increased the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex, but not in thalamus. In Fawn-Hooded rats, serotonin uptake (Vmax) was higher than in Sprague-Dawley rats cortex. Ethanol intake reduced the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex. In cortex, the carrier affinity for serotonin was increased in alcoholized Fawn-Hooded rats. These results indicate that synaptosomal {sup 3}H-serotonin uptake is affected by ethanol intake. In Fawn-Hooded rats, high ethanol consumption is associated with high serotonin uptake. In rats presenting high serotonin uptake, alcoholization reduces {sup 3}H-serotonin internalization in synaptosomes, indicating a specific sensitivity to alcohol intake of serotonin uptake system.

Authors:
; ; ;  [1]
  1. U.F.R. de Medecine et Pharmacie, Saint Etienne du Rouvray (France)
Publication Date:
OSTI Identifier:
5836800
Resource Type:
Journal Article
Journal Name:
Life Sciences; (USA)
Additional Journal Information:
Journal Volume: 48:20; Journal ID: ISSN 0024-3205
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ETHANOL; BIOLOGICAL EFFECTS; SEROTONIN; UPTAKE; CEREBRAL CORTEX; GENETIC VARIABILITY; HIPPOCAMPUS; INTAKE; METABOLISM; NERVE CELLS; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ALCOHOLS; AMINES; ANIMAL CELLS; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BIOLOGICAL VARIABILITY; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CEREBRUM; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RADIOPROTECTIVE SUBSTANCES; RODENTS; SOMATIC CELLS; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550501 - Metabolism- Tracer Techniques

Citation Formats

Daoust, M, Compagnon, P, Legrand, E, and Boucly, P. Ethanol intake and sup 3 H-serotonin uptake I: A study in Fawn-Hooded rats. United States: N. p., 1991. Web. doi:10.1016/0024-3205(91)90230-9.
Daoust, M, Compagnon, P, Legrand, E, & Boucly, P. Ethanol intake and sup 3 H-serotonin uptake I: A study in Fawn-Hooded rats. United States. https://doi.org/10.1016/0024-3205(91)90230-9
Daoust, M, Compagnon, P, Legrand, E, and Boucly, P. 1991. "Ethanol intake and sup 3 H-serotonin uptake I: A study in Fawn-Hooded rats". United States. https://doi.org/10.1016/0024-3205(91)90230-9.
@article{osti_5836800,
title = {Ethanol intake and sup 3 H-serotonin uptake I: A study in Fawn-Hooded rats},
author = {Daoust, M and Compagnon, P and Legrand, E and Boucly, P},
abstractNote = {Ethanol intake and synaptosomal {sup 3}H-serotonin uptake were studied in male Fawn-Hooded and Sprague-Dawley rats. Fawn-Hooded rats consumed more alcohol and more water than Sprague-Dawley rats. Plasma alcohol levels of Sprague-Dawley rats were not detectable but were about 5 mg/dl in Fawn-Hooded rats. Ethanol intake increased the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex, but not in thalamus. In Fawn-Hooded rats, serotonin uptake (Vmax) was higher than in Sprague-Dawley rats cortex. Ethanol intake reduced the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex. In cortex, the carrier affinity for serotonin was increased in alcoholized Fawn-Hooded rats. These results indicate that synaptosomal {sup 3}H-serotonin uptake is affected by ethanol intake. In Fawn-Hooded rats, high ethanol consumption is associated with high serotonin uptake. In rats presenting high serotonin uptake, alcoholization reduces {sup 3}H-serotonin internalization in synaptosomes, indicating a specific sensitivity to alcohol intake of serotonin uptake system.},
doi = {10.1016/0024-3205(91)90230-9},
url = {https://www.osti.gov/biblio/5836800}, journal = {Life Sciences; (USA)},
issn = {0024-3205},
number = ,
volume = 48:20,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1991},
month = {Tue Jan 01 00:00:00 EST 1991}
}