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Title: Radionuclide therapy for arthritic knees

Abstract

A new radionuclide therapeutic approach for rheumatoid arthritis of the knee is described. This therapy combines a short-lived radionuclide with a carrier whose physical and chemical characteristics aid retention of the radioactive particles within the joint. Joining a radionuclide to a particulate carrier had not been explored previously as a potential method for inhibiting radiation leakage. The treatment couples the rare earth element dysprosium 165 to ferric hydroxide in macroaggregate form (size range: 3 to 10 ..mu..m). After the relatively inert iron complex penetrates the synovium, it causes cell death. Macrophages and phagocytes clear away the cellular debris, essentially eliminating the synovium.

Authors:
Publication Date:
OSTI Identifier:
5833287
Resource Type:
Journal Article
Resource Relation:
Journal Name: JAMA, J. Am. Med. Assoc.; (United States); Journal Volume: 253:6
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DYSPROSIUM 165; TISSUE DISTRIBUTION; UPTAKE; RHEUMATIC DISEASES; RADIOTHERAPY; BONE JOINTS; COMPARATIVE EVALUATIONS; PATIENTS; RADIATION DOSES; RADIATION PROTECTION; RADIOPHARMACEUTICALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DISEASES; DISTRIBUTION; DOSES; DRUGS; DYSPROSIUM ISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; RARE EARTH ISOTOPES; RARE EARTH NUCLEI; SKELETAL DISEASES; SKELETON; THERAPY; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)

Citation Formats

Doepel, L.K. Radionuclide therapy for arthritic knees. United States: N. p., 1985. Web. doi:10.1001/jama.1985.03350300022003.
Doepel, L.K. Radionuclide therapy for arthritic knees. United States. doi:10.1001/jama.1985.03350300022003.
Doepel, L.K. Fri . "Radionuclide therapy for arthritic knees". United States. doi:10.1001/jama.1985.03350300022003.
@article{osti_5833287,
title = {Radionuclide therapy for arthritic knees},
author = {Doepel, L.K.},
abstractNote = {A new radionuclide therapeutic approach for rheumatoid arthritis of the knee is described. This therapy combines a short-lived radionuclide with a carrier whose physical and chemical characteristics aid retention of the radioactive particles within the joint. Joining a radionuclide to a particulate carrier had not been explored previously as a potential method for inhibiting radiation leakage. The treatment couples the rare earth element dysprosium 165 to ferric hydroxide in macroaggregate form (size range: 3 to 10 ..mu..m). After the relatively inert iron complex penetrates the synovium, it causes cell death. Macrophages and phagocytes clear away the cellular debris, essentially eliminating the synovium.},
doi = {10.1001/jama.1985.03350300022003},
journal = {JAMA, J. Am. Med. Assoc.; (United States)},
number = ,
volume = 253:6,
place = {United States},
year = {Fri Feb 08 00:00:00 EST 1985},
month = {Fri Feb 08 00:00:00 EST 1985}
}