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Title: Behavior of lead and zinc in plasma, erythrocytes, and urine and ALAD in erythrocytes following intravenous infusion of CaEDTA in lead workers

Abstract

To evaluate the effect of calcium disodium ethylenediamine tetraacetate (CaEDTA) on concentrations of lead and zinc in plasma, erythrocytes, whole blood, and urine, CaEDTA was administered by intravenous infusion for 1 hr to seven lead workers with blood lead concentrations of 46-67 ..mu..g/100 g (mean 54 ..mu..g/100 g). The plasma lead concentration (PPb) and the mobilization yield of lead in urine by CaEDTA were highest during the period between 1 and 2 hr after the infusion was started. In contrast, the lead concentration in erythrocytes (EPb) and in whole blood (BPb) remained unchanged during the 24 hr following infusion. Plasma zinc concentration (PZn) also fell rapidly following CaEDTA infusion; the decline was followed by a gradual rise in the zinc concentration in erythrocytes (EZn) without alteration in the zinc in whole blood. The mobilization yield of zinc in urine by CaEDTA (MZn) reached its highest level within 1 hr after the start of the infusion. Delta-aminolevulinic acid dehydratase (ALAD) activity in erythrocytes gradually increased for 5 hr following CaEDTA infusion. These observations suggest that (1) PPb concentration is a more sensitive indicator of the body burden of chelatable lead than is either BPb or EPb; (2) MZn is mobilized mostlymore » from plasma during the first several hours following the start of CaEDTA infusion, and the fall in PZn concentration following infusion is compensated first by a rise in EZn concentration and then by an immediate redistribution of zinc in other organs to the blood; and (3) Pb-inhibited ALAD activity is reactivated by the increased EZn during and shortly after CaEDTA infusion.« less

Authors:
; ; ;
Research Org.:
Medical College of Oita, Japan
OSTI Identifier:
5829160
Resource Type:
Journal Article
Journal Name:
Arch. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 39:5
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EDTA; BIOLOGICAL EFFECTS; LEAD; TISSUE DISTRIBUTION; LYASES; ENZYME REACTIVATION; ZINC; BLOOD; BLOOD PLASMA; BODY BURDEN; CALCIUM COMPOUNDS; DECONTAMINATION; ERYTHROCYTES; EXPERIMENTAL DATA; PERSONNEL; REMOVAL; TIME DEPENDENCE; URINE; ALKALINE EARTH METAL COMPOUNDS; AMINO ACIDS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEANING; DATA; DISTRIBUTION; ELEMENTS; ENZYMES; INFORMATION; MATERIALS; METALS; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; WASTES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)

Citation Formats

Araki, S, Aono, H, Fukahori, M, and Tabuki, K. Behavior of lead and zinc in plasma, erythrocytes, and urine and ALAD in erythrocytes following intravenous infusion of CaEDTA in lead workers. United States: N. p., Web. doi:10.1080/00039896.1984.10545865.
Araki, S, Aono, H, Fukahori, M, & Tabuki, K. Behavior of lead and zinc in plasma, erythrocytes, and urine and ALAD in erythrocytes following intravenous infusion of CaEDTA in lead workers. United States. https://doi.org/10.1080/00039896.1984.10545865
Araki, S, Aono, H, Fukahori, M, and Tabuki, K. . "Behavior of lead and zinc in plasma, erythrocytes, and urine and ALAD in erythrocytes following intravenous infusion of CaEDTA in lead workers". United States. https://doi.org/10.1080/00039896.1984.10545865.
@article{osti_5829160,
title = {Behavior of lead and zinc in plasma, erythrocytes, and urine and ALAD in erythrocytes following intravenous infusion of CaEDTA in lead workers},
author = {Araki, S and Aono, H and Fukahori, M and Tabuki, K},
abstractNote = {To evaluate the effect of calcium disodium ethylenediamine tetraacetate (CaEDTA) on concentrations of lead and zinc in plasma, erythrocytes, whole blood, and urine, CaEDTA was administered by intravenous infusion for 1 hr to seven lead workers with blood lead concentrations of 46-67 ..mu..g/100 g (mean 54 ..mu..g/100 g). The plasma lead concentration (PPb) and the mobilization yield of lead in urine by CaEDTA were highest during the period between 1 and 2 hr after the infusion was started. In contrast, the lead concentration in erythrocytes (EPb) and in whole blood (BPb) remained unchanged during the 24 hr following infusion. Plasma zinc concentration (PZn) also fell rapidly following CaEDTA infusion; the decline was followed by a gradual rise in the zinc concentration in erythrocytes (EZn) without alteration in the zinc in whole blood. The mobilization yield of zinc in urine by CaEDTA (MZn) reached its highest level within 1 hr after the start of the infusion. Delta-aminolevulinic acid dehydratase (ALAD) activity in erythrocytes gradually increased for 5 hr following CaEDTA infusion. These observations suggest that (1) PPb concentration is a more sensitive indicator of the body burden of chelatable lead than is either BPb or EPb; (2) MZn is mobilized mostly from plasma during the first several hours following the start of CaEDTA infusion, and the fall in PZn concentration following infusion is compensated first by a rise in EZn concentration and then by an immediate redistribution of zinc in other organs to the blood; and (3) Pb-inhibited ALAD activity is reactivated by the increased EZn during and shortly after CaEDTA infusion.},
doi = {10.1080/00039896.1984.10545865},
url = {https://www.osti.gov/biblio/5829160}, journal = {Arch. Environ. Health; (United States)},
number = ,
volume = 39:5,
place = {United States},
year = {},
month = {}
}