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Title: Effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH

Abstract

Experiments were performed to demonstrate that, while the shock-inducing dose of parent (toxic) endotoxin significantly decreases the serum T4 level of rats and inhibits the T4 response given to exogenous thyroid stimulating hormone (TSH), the radio-detoxified (/sup 60/Co-gamma, 150 kGy) endotoxin preparation does not inhibit the response to exogenous TSH. It also decreases serum T4 level to a lesser extent than untreated endotoxin.

Authors:
;
Publication Date:
Research Org.:
Frederic Joliot-Curie National Research Inst. for Radiobiology and Radiohygiene, Budapest, Hungary
OSTI Identifier:
5826172
Resource Type:
Journal Article
Journal Name:
Immunopharmacology; (United States)
Additional Journal Information:
Journal Volume: 8:3-4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ENDOTOXINS; BIOLOGICAL EFFECTS; THYROXINE; BIOCHEMICAL REACTION KINETICS; CELL MEMBRANES; COBALT 60; GAMMA RADIATION; LABELLED COMPOUNDS; RATS; THYROID; TRACER TECHNIQUES; AMINO ACIDS; ANIMALS; ANTIGENS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CELL CONSTITUENTS; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; GLANDS; HORMONES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; MATERIALS; MEMBRANES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIATIONS; RADIOISOTOPES; REACTION KINETICS; RODENTS; THYROID HORMONES; TOXIC MATERIALS; TOXINS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Bertok, L, and Nagy, S U. Effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH. United States: N. p., 1984. Web. doi:10.1016/0162-3109(84)90018-3.
Bertok, L, & Nagy, S U. Effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH. United States. https://doi.org/10.1016/0162-3109(84)90018-3
Bertok, L, and Nagy, S U. 1984. "Effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH". United States. https://doi.org/10.1016/0162-3109(84)90018-3.
@article{osti_5826172,
title = {Effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH},
author = {Bertok, L and Nagy, S U},
abstractNote = {Experiments were performed to demonstrate that, while the shock-inducing dose of parent (toxic) endotoxin significantly decreases the serum T4 level of rats and inhibits the T4 response given to exogenous thyroid stimulating hormone (TSH), the radio-detoxified (/sup 60/Co-gamma, 150 kGy) endotoxin preparation does not inhibit the response to exogenous TSH. It also decreases serum T4 level to a lesser extent than untreated endotoxin.},
doi = {10.1016/0162-3109(84)90018-3},
url = {https://www.osti.gov/biblio/5826172}, journal = {Immunopharmacology; (United States)},
number = ,
volume = 8:3-4,
place = {United States},
year = {Sat Dec 01 00:00:00 EST 1984},
month = {Sat Dec 01 00:00:00 EST 1984}
}