Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate
The acute toxicity of ethylene glycol monopropyl ether (EGPE) and ethylene-glycol monopropyl ether acetate (EGPEA) was determined in a series of standardized tests. The oral LD/sub 50/ in rats was 3089 and 9456 mg/kg EGPE and EGPEA, respectively. Skin irritation was slight following an occluded single dose application of either compound to the guinea pig abdomen. The dermal LD/sub 50/ for guinea pigs was 1 to 5 mL/kg and greater than 20 mL/kg EGPE and EGPEA, respectively. EGPE produced a very weak positive sensitization response in one of five guinea pigs. EGPE produced transient moderate to severe eye irritation in rabbits while EGPEA produced slight eye irritation. Subchronic toxicity was determined in a series of oral and inhalation studies. Groups of 10 male rats were dosed with 15, 7.5, 3.75 or 1.88 mmole/kg EGPE and 30, 15, or 7.5 mmole/kg EGPEA by gavage 5 days/week for 6 weeks. Hemoglobinuria was seen at least once at all dose levels of both compounds. EGPE had little effect on feed consumption or body weight gain, while body weight gain was reduced in the two high dose groups exposed to EGPEA and feed consumption was reduced at all dose levels. Hematologic changes were seen at all dose levels of both compounds. Absolute and/or relative spleen weights were increased at all but the lowest EGPE dose level and at all EGPEA dose levels. Gross and histopathologic examinations revealed significant effects on the spleen of animals exposed to EGPE and on the spleen, liver, kidney, and testes of animals exposed to EGPEA. Groups of 10 rats (5 M, 5 F) were exposed to 800, 400, 200 or 100 ppm EGPE or EGPEA 6 hr/day, 5 days/week for a total of 11 exposures. Body weight gains in all exposure groups were comparable to controls. 13 references, 13 figures, 9 tables.
- Research Organization:
- Eastman Kodak Co., Rochester, NY
- OSTI ID:
- 5824626
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 57
- Country of Publication:
- United States
- Language:
- English
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ETHERS
TOXICITY
GUINEA PIGS
SENSITIVITY
RABBITS
RATS
ACETATES
ACUTE EXPOSURE
DOSE-RESPONSE RELATIONSHIPS
EYES
GLYCOLS
KIDNEYS
LIVER
PATHOLOGICAL CHANGES
SKIN
SPLEEN
TESTES
WEIGHT
ALCOHOLS
ANIMALS
BODY
BODY AREAS
CARBOXYLIC ACID SALTS
DIGESTIVE SYSTEM
FACE
GLANDS
GONADS
HEAD
HYDROXY COMPOUNDS
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)