Comparative study of regional cerebral blood flow images by SPECT using xenon-133, iodine-123 IMP, and technetium-99m HM-PAO
Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography (SPECT) using /sup 133/Xe, N-isopropyl-p-(/sup 123/I)iodoamphetamine ((/sup 123/I)IMP) and (/sup 99m/Tc) hexamethylpropyleneamine oxime ((/sup 99m/Tc)HM-PAO) in 24 patients with cerebrovascular diseases. The greatest advantage of /sup 133/Xe SPECT was to be able to provide absolute rCBF values without arterial sampling. However, its image quality was very poor. Iodine-123 IMP SPECT provided rCBF images of higher quality and it had good correlation to /sup 133/Xe SPECT. Iodine-123 IMP SPECT provided the best images to detect mild ischemic lesions. It could detect obstructive or stenotic changes of large cerebral arteries very well except for a moderate stenosis of internal carotid artery. Technetium-99m HM-PAO SPECT also provided very good rCBF images and it had good correlation to /sup 133/Xe SPECT. However, the count-density ratios for the ischemic lesions to the contralateral presumed normal areas of (/sup 99m/Tc) HM-PAO SPECT were significantly higher than those of (/sup 123/I)IMP SPECT.
- Research Organization:
- Miyazaki Medical College (Japan)
- OSTI ID:
- 5821260
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 30:2
- Country of Publication:
- United States
- Language:
- English
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BRAIN
BLOOD FLOW
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
VASCULAR DISEASES
DIAGNOSIS
AMPHETAMINES
IODINE 123
ISOMERIC NUCLEI
OXIMES
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
XENON 133
AMINES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
SYMPATHOMIMETICS
TECHNETIUM ISOTOPES
TOMOGRAPHY
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics