skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Myocardial perfusion imaging with technetium-99m SQ30217: Comparison with thallium-201 and coronary anatomy

Abstract

Myocardial perfusion in ten normal volunteers and 20 patients with coronary artery disease documented by recent coronary arteriography was studied with 99mTc-labeled SQ30217 and /sup 201/TI. Plantar /sup 201/TI imaging followed standard treadmill exercise and planar SQ30217 imaging followed upright bicycle exercise, performed to angina, or the same double product achieved on the treadmill test. Upright anterior, 30 degrees left anterior oblique, and 60 degrees left anterior oblique images were obtained for 3, 6, and 9 min, respectively, starting 2 min after injection of 15 mCi of 99mTc SQ30217. A second 15-mCi dose was injected at rest approximately 2 hr later, and the same imaging protocol was followed. No adverse reactions or laboratory abnormalities attributable to SQ30217 were observed. All scans on the normal volunteers were interpreted as normal. Qualitative readings of both tests were equally sensitive for detecting patients with coronary disease (SQ30217 - 16/20, TI - 17/20, p = NS) and identifying abnormal vessels (SQ30217 - 19/45, TI - 21/45, p = NS). Both agents were falsely positive in 1/15 vessels. Ten vascular regions showed persistent abnormalities on resting SQ30217 scans; eight of these were distal to stenoses of at least 90% and three were also abnormal onmore » thallium redistribution images. Hepatic uptake of SQ30217 obscured inferoapical segments in some views in 14/20 patients but did not interfere with abnormal vessel identification.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Columbia Univ., New York, NY (USA)
OSTI Identifier:
5820272
Alternate Identifier(s):
OSTI ID: 5820272
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 30:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR DISEASES; DIAGNOSIS; MYOCARDIUM; RADIOISOTOPE SCANNING; RADIOPHARMACEUTICALS; COMPARATIVE EVALUATIONS; EXERCISE; ISOMERIC NUCLEI; ORGANOMETALLIC COMPOUNDS; OXIMES; PATIENTS; PERFUSED ORGANS; TECHNETIUM 99; THALLIUM 201; AMINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEART; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; TECHNETIUM ISOTOPES; THALLIUM ISOTOPES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Seldin, D.W., Johnson, L.L., Blood, D.K., Muschel, M.J., Smith, K.F., Wall, R.M., and Cannon, P.J.. Myocardial perfusion imaging with technetium-99m SQ30217: Comparison with thallium-201 and coronary anatomy. United States: N. p., 1989. Web.
Seldin, D.W., Johnson, L.L., Blood, D.K., Muschel, M.J., Smith, K.F., Wall, R.M., & Cannon, P.J.. Myocardial perfusion imaging with technetium-99m SQ30217: Comparison with thallium-201 and coronary anatomy. United States.
Seldin, D.W., Johnson, L.L., Blood, D.K., Muschel, M.J., Smith, K.F., Wall, R.M., and Cannon, P.J.. Wed . "Myocardial perfusion imaging with technetium-99m SQ30217: Comparison with thallium-201 and coronary anatomy". United States.
@article{osti_5820272,
title = {Myocardial perfusion imaging with technetium-99m SQ30217: Comparison with thallium-201 and coronary anatomy},
author = {Seldin, D.W. and Johnson, L.L. and Blood, D.K. and Muschel, M.J. and Smith, K.F. and Wall, R.M. and Cannon, P.J.},
abstractNote = {Myocardial perfusion in ten normal volunteers and 20 patients with coronary artery disease documented by recent coronary arteriography was studied with 99mTc-labeled SQ30217 and /sup 201/TI. Plantar /sup 201/TI imaging followed standard treadmill exercise and planar SQ30217 imaging followed upright bicycle exercise, performed to angina, or the same double product achieved on the treadmill test. Upright anterior, 30 degrees left anterior oblique, and 60 degrees left anterior oblique images were obtained for 3, 6, and 9 min, respectively, starting 2 min after injection of 15 mCi of 99mTc SQ30217. A second 15-mCi dose was injected at rest approximately 2 hr later, and the same imaging protocol was followed. No adverse reactions or laboratory abnormalities attributable to SQ30217 were observed. All scans on the normal volunteers were interpreted as normal. Qualitative readings of both tests were equally sensitive for detecting patients with coronary disease (SQ30217 - 16/20, TI - 17/20, p = NS) and identifying abnormal vessels (SQ30217 - 19/45, TI - 21/45, p = NS). Both agents were falsely positive in 1/15 vessels. Ten vascular regions showed persistent abnormalities on resting SQ30217 scans; eight of these were distal to stenoses of at least 90% and three were also abnormal on thallium redistribution images. Hepatic uptake of SQ30217 obscured inferoapical segments in some views in 14/20 patients but did not interfere with abnormal vessel identification.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 30:3,
place = {United States},
year = {1989},
month = {3}
}