Mouse models for understanding human developmental anomalies

Conference · Sun Jan 01 00:00:00 EST 1989

OSTI ID:5811699

Generoso, W M

The mouse experimental system presents an opportunity for studying the nature of the underlying mutagenic damage and the molecular pathogenesis of this class of anomalies by virtue of the accessibility of the zygote and its descendant blastomeres. Such studies could contribute to the understanding of the etiology of certain sporadic but common human malformations. The vulnerability of the zygotes to mutagens as demonstrated in the studies described in this report should be a major consideration in chemical safety evaluation. It raises questions regarding the danger to human zygotes when the mother is exposed to drugs and environmental chemicals.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5811699
• Report Number(s): CONF-8907113-1; ON: DE89015073
• Resource Relation: Conference: 5. international conference on environmental mutagens, Cleveland, OH, USA, 10-15 Jul 1989; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
MICE
MUTAGENESIS
MUTAGENS
OCCUPATIONAL EXPOSURE
CHROMOSOMAL ABERRATIONS
GENETIC CONTROL
GENETICS
HEREDITARY DISEASES
TERATOGENESIS
TESTING
TRANSLOCATION
ANIMALS
BIOLOGY
CONTROL
DISEASES
MAMMALS
MUTATIONS
PEST CONTROL
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry
550400 - Genetics