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Title: Neurotensin receptor binding levels in basal ganglia are not altered in Huntington's chorea or schizophrenia

Abstract

Autoradiographic techniques were used to examine the distribution and levels of neurotensin receptor binding sites in the basal ganglia and related regions of the human brain. Monoiodo ({sup 125}I-Tyr3)neurotensin was used as a ligand. High amounts of neurotensin receptor binding sites were found in the substantia nigra pars compacta. Lower but significant quantities of neurotensin receptor binding sites characterized the caudate, putamen, and nucleus accumbens, while very low quantities were seen in both medial and lateral segments of the globus pallidus. In Huntington's chorea, the levels of neurotensin receptor binding sites were found to be comparable to those of control cases. Only slight but not statistically significant decreases in amounts of receptor binding sites were detected in the dorsal part of the head and in the body of caudate nucleus. No alterations in the levels of neurotensin receptor binding sites were observed in the substantia nigra pars compacta and reticulata. These results suggest that a large proportion of neurotensin receptor binding sites in the basal ganglia are located on intrinsic neurons and on extrinsic afferent fibers that do not degenerate in Huntington's disease.

Authors:
; ; ; ;  [1]
  1. (Sandoz Pharma Ltd., Basel (Switzerland))
Publication Date:
OSTI Identifier:
5800954
Resource Type:
Journal Article
Resource Relation:
Journal Name: Synapse (New York); (USA); Journal Volume: 7:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; NERVOUS SYSTEM DISEASES; PATHOGENESIS; PEPTIDES; RECEPTORS; TISSUE DISTRIBUTION; AUTORADIOGRAPHY; BIOCHEMICAL REACTION KINETICS; BRAIN; IODINE 125; LIGANDS; MAN; NERVE CELLS; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MEMBRANE PROTEINS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; PROTEINS; RADIOISOTOPES; REACTION KINETICS; SOMATIC CELLS; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Palacios, J.M., Chinaglia, G., Rigo, M., Ulrich, J., and Probst, A.. Neurotensin receptor binding levels in basal ganglia are not altered in Huntington's chorea or schizophrenia. United States: N. p., 1991. Web. doi:10.1002/syn.890070205.
Palacios, J.M., Chinaglia, G., Rigo, M., Ulrich, J., & Probst, A.. Neurotensin receptor binding levels in basal ganglia are not altered in Huntington's chorea or schizophrenia. United States. doi:10.1002/syn.890070205.
Palacios, J.M., Chinaglia, G., Rigo, M., Ulrich, J., and Probst, A.. Fri . "Neurotensin receptor binding levels in basal ganglia are not altered in Huntington's chorea or schizophrenia". United States. doi:10.1002/syn.890070205.
@article{osti_5800954,
title = {Neurotensin receptor binding levels in basal ganglia are not altered in Huntington's chorea or schizophrenia},
author = {Palacios, J.M. and Chinaglia, G. and Rigo, M. and Ulrich, J. and Probst, A.},
abstractNote = {Autoradiographic techniques were used to examine the distribution and levels of neurotensin receptor binding sites in the basal ganglia and related regions of the human brain. Monoiodo ({sup 125}I-Tyr3)neurotensin was used as a ligand. High amounts of neurotensin receptor binding sites were found in the substantia nigra pars compacta. Lower but significant quantities of neurotensin receptor binding sites characterized the caudate, putamen, and nucleus accumbens, while very low quantities were seen in both medial and lateral segments of the globus pallidus. In Huntington's chorea, the levels of neurotensin receptor binding sites were found to be comparable to those of control cases. Only slight but not statistically significant decreases in amounts of receptor binding sites were detected in the dorsal part of the head and in the body of caudate nucleus. No alterations in the levels of neurotensin receptor binding sites were observed in the substantia nigra pars compacta and reticulata. These results suggest that a large proportion of neurotensin receptor binding sites in the basal ganglia are located on intrinsic neurons and on extrinsic afferent fibers that do not degenerate in Huntington's disease.},
doi = {10.1002/syn.890070205},
journal = {Synapse (New York); (USA)},
number = ,
volume = 7:2,
place = {United States},
year = {Fri Feb 01 00:00:00 EST 1991},
month = {Fri Feb 01 00:00:00 EST 1991}
}