New methods applied to the analysis and treatment of ovarian cancer. [Colloidal /sup 32/P therapy; /sup 99m/Tc-scanning]

Journal Article · Fri Jun 01 00:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90071-3· OSTI ID:5795088

Order, S E; Rosenshein, N B; Klein, J L; Lichter, A S; Ettinger, D S; Dillon, M B; Leibel, S A

The development of rigorous staging methods, appreciation of new knowledge concerning ovarian cancer dissemination, and administration of new treatment techniques have been applied to ovarian cancer. The method of staging consists of peritoneal cytology, total abdominal hysterectomy-bilateral salpingo oophorectomy (TAH-BSO), omentectomy, nodal biopsy, diaphragmatic inspection and is coupled with maximal surgical resection. An additional examination being evaluated for usefulness in future staging is intraperitoneal /sup 99m/Tc sulfur colloid scans. Nineteen patients have entered the pilot studies. Sixteen patients (5 Stage 2, 10 Stage 3 micrometastatic, and 1 Stage 4) have been treated with colloidal /sup 32/P, i.p. followed 2 weeks later by split abdominal irradiation (200 rad fractions pelvis-2 hr rest-150 rad upper abdomen) to a total abdominal dose of 3000 rad with a pelvic cone down to 4000 rad. Five of these patients received Phenylalanine mustard (L-PAM) (7 mg/m/sup 2/) maintenance therapy. The 3 year actuarial survival was 78% and the 3 year disease free actuarial survival 68%. Seven patients were treated with intraperitoneal tumor antisera and 4/7 remain in complete remission as of this writing. The specificity of the antiserum has been demonstrated by immunoelectrophoresis in 4/4 patients, and by live cell fluorescence in 1 patient. Rabbit IgG levels revealed significant increasing titers in 4/6 patients following i.p. antiovarian antiserum. Radiolabeled IgG derived from the antiserum demonstrated tumor localization and correlation with conventional radiograhy and computerized axial tomograhy (CAT) scans in 2 patients studied to date. Biomarker analysis reveals that free secretory protein 6/6, apha globulin 5/6, and CEA (carcinoembryonic antigen) 3/6 were elevated in the 6 patients studied. Two patients whose disease progressed demonstrated elevated levels of all three biomarkers.

• Research Organization: Johns Hopkins Univ., Baltimore, MD
• OSTI ID: 5795088
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD CELLS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
SIDE EFFECTS
HEMIC DISEASES
RADIOINDUCTION
OVARIES
SCINTISCANNING
RADIOTHERAPY
STOMACH
TECHNETIUM 99
ULCERS
ABDOMEN
CARCINOMAS
CAT SCANNING
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
IMMUNE SERUMS
INTRAPERITONEAL INJECTION
ISOLATED VALUES
PATIENTS
PHOSPHORUS 32
RADIOCOLLOIDS
SULFUR COMPLEXES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY AREAS
BODY FLUIDS
COLLOIDS
COMPLEXES
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
FEMALE GENITALS
GASTROINTESTINAL TRACT
GONADS
HOURS LIVING RADIOISOTOPES
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORUS ISOTOPES
PHOTON TRANSMISSION SCANNING
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
TECHNETIUM ISOTOPES
THERAPY
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
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550603 - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)