skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea

Abstract

Specific-pathogen-free rats were exposed to 400 ppM sulfur dioxide daily for up to 7 weeks. At intervals during exposure, tracheas were removed and incubated in vitro in culture medium containing radioactive glycoprotein precursors. The most prominent histological changes due to SO/sub 2/ were progressive hypertrophy and hyperplasia of the submucosal mucous glands accompanied by a flattening of the epithelium with eventual recovery. Uptake of radioactive precursors into a highly purified mucin fraction correlated with these histological changes in the submucosal mucous glands, increasing progressively up to 4 times that of control. Uptake of precursors into specific mucins purified by DEAE-Sephacel showed that uptake into the 0.2 and 0.3 M NaCl fractions was stimulated several fold by SO/sub 2/, and uptake into more highly acidic fractions, which was nearly absent in the control, was also greatly increased. Two weeks following the last exposure of the tracheas to SO/sub 2/, their morphological and mucus-secreting properties showed signs of returning to that of the control.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of Tennessee, Oak Ridge
OSTI Identifier:
5793160
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Journal Article
Journal Name:
J. Environ. Pathol. Toxicol.; (United States)
Additional Journal Information:
Journal Volume: 4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; MUCOUS MEMBRANES; PATHOLOGICAL CHANGES; SULFUR DIOXIDE; BIOLOGICAL EFFECTS; TRACHEA; MORPHOLOGICAL CHANGES; BIOLOGICAL RECOVERY; BIOSYNTHESIS; CHRONIC EXPOSURE; EXPOSURE CHAMBERS; GERM-FREE ANIMALS; INHALATION; MUCOPROTEINS; RATS; ANIMALS; CARBOHYDRATES; CHALCOGENIDES; INTAKE; MAMMALS; MEMBRANES; ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; POLYSACCHARIDES; PROTEINS; RECOVERY; RESPIRATORY SYSTEM; RODENTS; SACCHARIDES; SULFUR COMPOUNDS; SULFUR OXIDES; SYNTHESIS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550300 - Cytology; 551000 - Physiological Systems

Citation Formats

Clark, J N, Dalbey, W E, and Stephenson, K B. Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea. United States: N. p., 1980. Web.
Clark, J N, Dalbey, W E, & Stephenson, K B. Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea. United States.
Clark, J N, Dalbey, W E, and Stephenson, K B. 1980. "Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea". United States.
@article{osti_5793160,
title = {Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea},
author = {Clark, J N and Dalbey, W E and Stephenson, K B},
abstractNote = {Specific-pathogen-free rats were exposed to 400 ppM sulfur dioxide daily for up to 7 weeks. At intervals during exposure, tracheas were removed and incubated in vitro in culture medium containing radioactive glycoprotein precursors. The most prominent histological changes due to SO/sub 2/ were progressive hypertrophy and hyperplasia of the submucosal mucous glands accompanied by a flattening of the epithelium with eventual recovery. Uptake of radioactive precursors into a highly purified mucin fraction correlated with these histological changes in the submucosal mucous glands, increasing progressively up to 4 times that of control. Uptake of precursors into specific mucins purified by DEAE-Sephacel showed that uptake into the 0.2 and 0.3 M NaCl fractions was stimulated several fold by SO/sub 2/, and uptake into more highly acidic fractions, which was nearly absent in the control, was also greatly increased. Two weeks following the last exposure of the tracheas to SO/sub 2/, their morphological and mucus-secreting properties showed signs of returning to that of the control.},
doi = {},
url = {https://www.osti.gov/biblio/5793160}, journal = {J. Environ. Pathol. Toxicol.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1980},
month = {Tue Jan 01 00:00:00 EST 1980}
}