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Title: Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension

Abstract

This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/l in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl) diet for 28 weeks. Cadmium produced hypertension associated with gross cardiac hypertrophy and mild to moderate renal vascular changes in S, but not in R, rats on a low salt diet. Cadmium enhanced the rate and degree of development of salt-induced hypertension without the hypercholesterolemia or renal vascular lesions normally observed in S rats on a high salt diet. Cadmium lowered circulating cholesterol levels in both lines on a low salt diet. Cadmium had no influence on growth, blood urea nitrogen concentration, plasma renin activity, tumor formation, or survivorship in R and S rats on either salt diet. This study indicates that the genetic composition is a critical determinant of the adverse effects of chronic low-level cadmium ingestion in rats. In addition to the experimental implications, these findings may have relevance to the problem of human essential hypertension.

Authors:
;
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, NY
OSTI Identifier:
5792954
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 28
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; BIOLOGICAL EFFECTS; HYPERTENSION; TOXICITY; RESPONSE MODIFYING FACTORS; ANIMAL GROWTH; BIOLOGICAL VARIABILITY; CARCINOGENESIS; CARDIOVASCULAR DISEASES; CHOLESTEROL; DIET; FEMALES; GENETIC CONTROL; HEART; HYPERTROPHY; INGESTION; KIDNEYS; RATS; RENIN; SODIUM CHLORIDES; SURVIVAL TIME; UREA; ALKALI METAL COMPOUNDS; AMIDES; ANIMALS; BODY; CARBONIC ACID DERIVATIVES; CARDIOVASCULAR SYSTEM; CHLORIDES; CHLORINE COMPOUNDS; DISEASES; ELEMENTS; ENZYMES; GROWTH; HALIDES; HALOGEN COMPOUNDS; HYDROLASES; HYDROXY COMPOUNDS; INTAKE; MAMMALS; METALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOGENESIS; PATHOLOGICAL CHANGES; PEPTIDE HYDROLASES; PEST CONTROL; RODENTS; SODIUM COMPOUNDS; STEROIDS; STEROLS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 551000* - Physiological Systems; 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Ohanian, E.V., and Iwai, J. Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension. United States: N. p., 1979. Web. doi:10.1289/ehp.7928261.
Ohanian, E.V., & Iwai, J. Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension. United States. doi:10.1289/ehp.7928261.
Ohanian, E.V., and Iwai, J. Thu . "Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension". United States. doi:10.1289/ehp.7928261.
@article{osti_5792954,
title = {Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension},
author = {Ohanian, E.V. and Iwai, J.},
abstractNote = {This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/l in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl) diet for 28 weeks. Cadmium produced hypertension associated with gross cardiac hypertrophy and mild to moderate renal vascular changes in S, but not in R, rats on a low salt diet. Cadmium enhanced the rate and degree of development of salt-induced hypertension without the hypercholesterolemia or renal vascular lesions normally observed in S rats on a high salt diet. Cadmium lowered circulating cholesterol levels in both lines on a low salt diet. Cadmium had no influence on growth, blood urea nitrogen concentration, plasma renin activity, tumor formation, or survivorship in R and S rats on either salt diet. This study indicates that the genetic composition is a critical determinant of the adverse effects of chronic low-level cadmium ingestion in rats. In addition to the experimental implications, these findings may have relevance to the problem of human essential hypertension.},
doi = {10.1289/ehp.7928261},
journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 28,
place = {United States},
year = {1979},
month = {2}
}