Comparison of the subcellular distribution of monomeric /sup 239/Pu and /sup 59/Fe in the liver of rat, mouse, and Syrian and Chinese hamsters
The subcellular distribution of /sup 239/Pu and /sup 59/Fe 10 days after intravenous injection as a citrate complex was investigated by sucrose density gradient centrifugation in the liver of rat, mouse, and Syrian and Chinese hamsters. Lysosomes were separated from other cell constituents by injection of the nonionic detergent Triton WR 1339 4 days before sacrifice. The Triton-induced decrease in the density of the lysosomes was very similar in all four animal species and was followed closely by a corresponding decrease of the median density of the /sup 239/Pu profiles in rat, mouse, and, to a smaller extent, Syrian hamster. However, in Chinese hamster a clear correspondence between lysosomes and /sup 239/Pu was not found 10 days after nuclide injection. It was concluded that lysosomes are the main storage organelles fo /sup 239/Pu in the liver of rat and mouse and that in all four animal species mitochondria and endoplasmic reticulum do not play any significant role in binding the radionuclide. The relevance of pericellular membranes has to be checked. The distribution patterns of /sup 59/Fe and /sup 239/Pu were quite different.
- Research Organization:
- Institut fur Genetik und fur Toxikologie von Spaltstoffe, Karlsrahe, Federal Republic of Germany
- OSTI ID:
- 5792721
- Journal Information:
- Radiat. Res.; (United States), Vol. 89:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IRON 59
TISSUE DISTRIBUTION
PLUTONIUM 239
COMPARATIVE EVALUATIONS
HAMSTERS
INTRAVENOUS INJECTION
LIVER
LYSOSOMES
MICE
RATS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CELL CONSTITUENTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ORGANOIDS
ORGANS
PLUTONIUM ISOTOPES
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells