Role of dopamine receptor and muscarinic acetylcholine receptor blockade in the antiapomorphine action of neuroleptics
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The authors analyze the role of dopamine and muscarinic acetylcholine receptor blocking components in the antistereotypic action of neuroleptics with different chemical structure. To determine dopamine-blocking activity in vitro, binding of /sup 3/H-spiperone with membranes of the rat striatum was measured. To study the blocking action of the substances on muscarinic acetylcholine receptors, binding of /sup 3/H-quinuclidinyl benzylate with brain membranes was chosen.
- Research Organization:
- Tartu State Univ., USSR
- OSTI ID:
- 5783435
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 103:3; Other Information: Translated from Byulleten Ehksperimental'noj Biologii i Meditsiny; 103: No. 3, 317-319(Mar 1987)
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5783435
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
RECEPTORS
DOPAMINE
DRUGS
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
NERVE CELLS
RADIORECEPTOR ASSAY
BINDING ENERGY
BRAIN
CELL MEMBRANES
CHEMICAL COMPOSITION
INHIBITION
LABELLING
MICE
MORPHINE
RATS
TRITIUM COMPOUNDS
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
ANALGESICS
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
ENERGY
ESTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NARCOTICS
NERVOUS SYSTEM
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PHENOLS
POLYPHENOLS
PROTEINS
QUATERNARY COMPOUNDS
RODENTS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES
550301* - Cytology- Tracer Techniques
550201 - Biochemistry- Tracer Techniques
ACETYLCHOLINE
RECEPTORS
DOPAMINE
DRUGS
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
NERVE CELLS
RADIORECEPTOR ASSAY
BINDING ENERGY
BRAIN
CELL MEMBRANES
CHEMICAL COMPOSITION
INHIBITION
LABELLING
MICE
MORPHINE
RATS
TRITIUM COMPOUNDS
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
ANALGESICS
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
ENERGY
ESTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NARCOTICS
NERVOUS SYSTEM
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PHENOLS
POLYPHENOLS
PROTEINS
QUATERNARY COMPOUNDS
RODENTS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES
550301* - Cytology- Tracer Techniques
550201 - Biochemistry- Tracer Techniques