Background and stimulus-induced patterns of high metabolic activity in the visual cortex (area 17) of the squirrel and macaque monkey
The authors have used 2-deoxy-D-(/sup 14/C)glucose (2-DG) autoradiography and cytochrome oxidase histochemistry to examine background and stimulus-induced patterns of metabolic activity in monkey striate cortex. In squirrel monkeys (Saimiri sciureus) that binocularly or monocularly viewed diffuse white light or binocularly viewed bars of many orientations and spatial frequencies, 2-DG consumption was not uniform across the cortex but consisted of regularly spaced radial zones of high uptake. The cytochrome oxidase stain in these animals also revealed patches of high metabolism which coincided with the 2-DG patches. Squirrel monkeys binocularly viewing vertical stripes showed parallel bands of increased 2-DG uptake in the cortex, while the cytochrome label in these animals remained patchy. In macaque (Macaca nemestrina) monkeys, binocular stimulation with many orientations and spatial frequencies produced radial zones of high 2-DG uptake. When viewed tangentially, these zones formed a dots-in-rows pattern with a spacing of 350 X 500 microns; cytochrome oxidase staining produced an identical pattern. Macaca differed from Saimiri in that monocular stimulation labeled alternate rows. These results indicate that there are radial zones of high background metabolism across squirrel and macaque monkey striate cortex. In Saimiri these zones do not appear to be related to an eye dominance system, while in Macaca they do. The presence of these zones of high metabolism may complicate the interpretation of 2-DG autoradiographs that result from specific visual stimuli.
- Research Organization:
- Univ. of Washington School of Medicine, Seattle
- OSTI ID:
- 5777720
- Journal Information:
- J. Neurosci.; (United States), Vol. 3:2
- Country of Publication:
- United States
- Language:
- English
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CARBON 14 COMPOUNDS
AUTORADIOGRAPHY
CEREBRAL CORTEX
PHYSIOLOGY
CYTOCHROME OXIDASE
CYTOCHEMISTRY
HEXOSES
EYES
MACACUS
MONKEYS
VISION
ANIMALS
BIOCHEMISTRY
BODY
BODY AREAS
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHEMISTRY
ENZYMES
FACE
HAEM DEHYDROGENASES
HEAD
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PRIMATES
SACCHARIDES
SENSE ORGANS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques