Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and /sup 15/O-water
A noninvasive method that employs /sup 15/O-water and positron-computed tomography (PCT) was used to measure quantitative local cerebral blood flow (lCBF) in man. /sup 15/O-Water (about 30-50 mCi) was introduced through a single-breath inhalation of /sup 15/O-carbon dioxide or through an intravenous bolus injection of /sup 15/O-water. A sequence of five 2-min PCT scans was initiated at the time of tracer administration. A series of 15-20 blood samples (1 ml each) was withdrawn from the radial artery of the subject over a period of 10 min. Oxygen-15 radioactivities in the blood samples were immediately counted in a well counter to give an input function, which together with the projection data collected by PCT were processed to provide images of 1CBF and local water distribution volume. The method was found to be convenient to use and gave good-quality images of 1CBF. Quantitative values of 1CBF in images were 59 +/- 11 and 20 +/- 4 ml/min/100 g for gray and white matter, respectively, with a gray-to-white matter ratio of 2.93 and a global flow value of 42 +/- 8 ml/min/100 g. Distribution volume of water was 0.85 +/- 0.03, 0.76 +/- 0.03, and 0.81 +/- 0.02 ml/g respectively, for gray matter, white matter, and whole brain.
- Research Organization:
- Department of Radiological Sciences, UCLA School of Medicine
- OSTI ID:
- 5776303
- Journal Information:
- J. Cereb. Blood Flow Metab.; (United States), Vol. 3:2
- Country of Publication:
- United States
- Language:
- English
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BRAIN
BLOOD FLOW
POSITRON COMPUTED TOMOGRAPHY
CARBON DIOXIDE
INHALATION
LABELLED COMPOUNDS
OXYGEN 15
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)