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Title: Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids

Abstract

Average life spans were estimated for the male progeny from 21 of the 25 possible matings of 5 inbred mouse strains. Oxygen consumption was measured in an open system over a 48-hour interval. Resting metabolism, M/sub re/, and average metabolism, M/sub av/, were determined at 6 to 8 months of age, and at 24 to 34 months. Body weight, W, was determined at the time metabolism was measured. Life span, L, is negatively correlated with M/sub re/ and M/sub av/, and positively correlated with W at both ages of measurement. This is in accord with the metabolic wear factor that had previously been established among 85 different species of mammals. A new metabolism variable, the energy partition coefficient, defined as the ratio of average to resting metabolic rate, M/sub av//M/sub re/, has a parabolic relation to body weight, i.e., is maximal at an intermediate body size. The squared body weight deviation in turn has a negative correlation with life span. The correlation of L with M/sub av//M/sub re/ is positive, as expected, but not significant. These data suggest the existence of a longevity factor dependent on the partition of energy between the phasic metabolism of activity and the continuous maintenancemore » metabolism.« less

Authors:
;
Publication Date:
Research Org.:
Argonne National Lab., IL
OSTI Identifier:
5775168
Resource Type:
Journal Article
Journal Name:
Fed. Proc.; (United States)
Additional Journal Information:
Journal Volume: 38:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; LIFE SPAN; RESPONSE MODIFYING FACTORS; MICE; GENETIC VARIABILITY; GENETICS; HYBRIDIZATION; METABOLISM; WEIGHT; ANIMALS; BIOLOGICAL VARIABILITY; BIOLOGY; MAMMALS; RODENTS; VERTEBRATES; 550500* - Metabolism; 550400 - Genetics

Citation Formats

Sacher, G.A., and Duffy, P.H. Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids. United States: N. p., 1979. Web.
Sacher, G.A., & Duffy, P.H. Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids. United States.
Sacher, G.A., and Duffy, P.H. Thu . "Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids". United States.
@article{osti_5775168,
title = {Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids},
author = {Sacher, G.A. and Duffy, P.H.},
abstractNote = {Average life spans were estimated for the male progeny from 21 of the 25 possible matings of 5 inbred mouse strains. Oxygen consumption was measured in an open system over a 48-hour interval. Resting metabolism, M/sub re/, and average metabolism, M/sub av/, were determined at 6 to 8 months of age, and at 24 to 34 months. Body weight, W, was determined at the time metabolism was measured. Life span, L, is negatively correlated with M/sub re/ and M/sub av/, and positively correlated with W at both ages of measurement. This is in accord with the metabolic wear factor that had previously been established among 85 different species of mammals. A new metabolism variable, the energy partition coefficient, defined as the ratio of average to resting metabolic rate, M/sub av//M/sub re/, has a parabolic relation to body weight, i.e., is maximal at an intermediate body size. The squared body weight deviation in turn has a negative correlation with life span. The correlation of L with M/sub av//M/sub re/ is positive, as expected, but not significant. These data suggest the existence of a longevity factor dependent on the partition of energy between the phasic metabolism of activity and the continuous maintenance metabolism.},
doi = {},
journal = {Fed. Proc.; (United States)},
number = ,
volume = 38:2,
place = {United States},
year = {1979},
month = {2}
}