skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biomedical studies on solvent refined coal (SRC-II) liquefaction materials: a status report

Abstract

This technical report summarizes the results of biomedical research effort on solvent refined coal (SRC) materials. The samples, described in the text, as well as samples of raw shale oil, crude petroleum, and some SRC-I materials were evaluated for biological activity in several different systems: (1) microbial mutagenesis (Ames assay), coupled to chemical characterization efforts, (2) in vitro mammalian cell toxicity and transformation, (3) epidermal carcinogenesis (skin painting) in mice, (4) acute and subchronic oral toxicity in rats, (5) developmental toxicity in rats, and (6) dosimetry and metabolism in rats. High boiling point materials (identified) showed significant mutagenic activity while lower boiling fractions from both processes were inactive; crude petroleum was also inactive, while raw shale oil showed only a low level of activity. Chemical characterization studies suggested that 3- and 4-ring primary aromatic amines are responsible for a large fraction of the mutagenic activity. Cultured mammalian cell studies showed that materials exhibiting a positive effect in the Ames system also caused mammalian cell transformation. The results of skin carcinogenesis studies in the mouse were generally consistent with those of the cellular studies. Light distillates were found to be moderately toxic after oral administration to rats. Fuel upgrading, process modification,more » and appropriate occupational/environmental controls may ameliorate some of the biological effects of SRC materials and other coal liquids of high boiling point. Low-boiling SRC liquids appear to have little biological effects in the assays employed. (LTN)« less

Publication Date:
Research Org.:
Battelle Pacific Northwest Labs., Richland, WA (USA)
OSTI Identifier:
5767728
Report Number(s):
PNL-3189
DOE Contract Number:  
EY-76-C-06-1830
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
01 COAL, LIGNITE, AND PEAT; 04 OIL SHALES AND TAR SANDS; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 02 PETROLEUM; COAL LIQUIDS; BIOLOGICAL EFFECTS; CARCINOGENESIS; MUTAGEN SCREENING; TOXICITY; PETROLEUM; SHALE OIL; SRC-II PROCESS; CELL CULTURES; CHEMICAL EFFLUENTS; COAL LIQUEFACTION; EXPERIMENTAL DATA; GAS CHROMATOGRAPHY; GRAPHS; MASS SPECTROSCOPY; PILOT PLANTS; POLYCYCLIC AROMATIC HYDROCARBONS; RATS; SAMPLING; TABLES; ANIMALS; AROMATICS; CHROMATOGRAPHY; DATA; DATA FORMS; ENERGY SOURCES; FOSSIL FUELS; FUELS; FUNCTIONAL MODELS; HYDROCARBONS; INFORMATION; LIQUEFACTION; MAMMALS; MINERAL OILS; NUMERICAL DATA; OILS; ORGANIC COMPOUNDS; OTHER ORGANIC COMPOUNDS; PATHOGENESIS; RODENTS; SCREENING; SEPARATION PROCESSES; SPECTROSCOPY; SYNTHETIC FUELS; SYNTHETIC PETROLEUM; THERMOCHEMICAL PROCESSES; VERTEBRATES; 016000* - Coal, Lignite, & Peat- Health & Safety; 040700 - Oil Shales & Tar Sands- Health & Safety; 560300 - Chemicals Metabolism & Toxicology; 020600 - Petroleum- Health & Safety

Citation Formats

. Biomedical studies on solvent refined coal (SRC-II) liquefaction materials: a status report. United States: N. p., 1979. Web. doi:10.2172/5767728.
. Biomedical studies on solvent refined coal (SRC-II) liquefaction materials: a status report. United States. doi:10.2172/5767728.
. Mon . "Biomedical studies on solvent refined coal (SRC-II) liquefaction materials: a status report". United States. doi:10.2172/5767728. https://www.osti.gov/servlets/purl/5767728.
@article{osti_5767728,
title = {Biomedical studies on solvent refined coal (SRC-II) liquefaction materials: a status report},
author = {},
abstractNote = {This technical report summarizes the results of biomedical research effort on solvent refined coal (SRC) materials. The samples, described in the text, as well as samples of raw shale oil, crude petroleum, and some SRC-I materials were evaluated for biological activity in several different systems: (1) microbial mutagenesis (Ames assay), coupled to chemical characterization efforts, (2) in vitro mammalian cell toxicity and transformation, (3) epidermal carcinogenesis (skin painting) in mice, (4) acute and subchronic oral toxicity in rats, (5) developmental toxicity in rats, and (6) dosimetry and metabolism in rats. High boiling point materials (identified) showed significant mutagenic activity while lower boiling fractions from both processes were inactive; crude petroleum was also inactive, while raw shale oil showed only a low level of activity. Chemical characterization studies suggested that 3- and 4-ring primary aromatic amines are responsible for a large fraction of the mutagenic activity. Cultured mammalian cell studies showed that materials exhibiting a positive effect in the Ames system also caused mammalian cell transformation. The results of skin carcinogenesis studies in the mouse were generally consistent with those of the cellular studies. Light distillates were found to be moderately toxic after oral administration to rats. Fuel upgrading, process modification, and appropriate occupational/environmental controls may ameliorate some of the biological effects of SRC materials and other coal liquids of high boiling point. Low-boiling SRC liquids appear to have little biological effects in the assays employed. (LTN)},
doi = {10.2172/5767728},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1979},
month = {10}
}