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Title: Acute effects of cigarette smoke exposure on experimental skin flaps

Abstract

Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Illinois Medical Center, Chicago
OSTI Identifier:
5766539
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Journal Article
Resource Relation:
Journal Name: Plast. Reconstr. Surg.; (United States); Journal Volume: 75:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; SKIN; NECROSIS; TOBACCO SMOKES; TOXICITY; BIOLOGICAL MODELS; EXPERIMENTAL DATA; INHALATION; PATHOGENESIS; RATS; RISK ASSESSMENT; SURGERY; AEROSOLS; ANIMALS; BODY; COLLOIDS; DATA; DISPERSIONS; INFORMATION; INTAKE; MAMMALS; MEDICINE; NUMERICAL DATA; ORGANS; PATHOLOGICAL CHANGES; RESIDUES; RODENTS; SMOKES; SOLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550900 - Pathology

Citation Formats

Nolan, J., Jenkins, R.A., Kurihara, K., and Schultz, R.C. Acute effects of cigarette smoke exposure on experimental skin flaps. United States: N. p., 1985. Web. doi:10.1097/00006534-198504000-00018.
Nolan, J., Jenkins, R.A., Kurihara, K., & Schultz, R.C. Acute effects of cigarette smoke exposure on experimental skin flaps. United States. doi:10.1097/00006534-198504000-00018.
Nolan, J., Jenkins, R.A., Kurihara, K., and Schultz, R.C. Mon . "Acute effects of cigarette smoke exposure on experimental skin flaps". United States. doi:10.1097/00006534-198504000-00018.
@article{osti_5766539,
title = {Acute effects of cigarette smoke exposure on experimental skin flaps},
author = {Nolan, J. and Jenkins, R.A. and Kurihara, K. and Schultz, R.C.},
abstractNote = {Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study.},
doi = {10.1097/00006534-198504000-00018},
journal = {Plast. Reconstr. Surg.; (United States)},
number = ,
volume = 75:4,
place = {United States},
year = {Mon Apr 01 00:00:00 EST 1985},
month = {Mon Apr 01 00:00:00 EST 1985}
}