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Title: Effect of rate-dependent left bundle branch block on global and regional left ventricular function

Abstract

Seven subjects with rate-dependent left bundle branch block (RDLBBB) and 13 subjects with normal conduction (control group) underwent upright bicycle exercise radionuclide angiography to determine the effects of the development of RDLBBB on global and regional left ventricular function. Six of the seven subjects with RDLBBB had atypical chest pain syndromes; none had evidence of cardiac disease based on clinical examination and either normal cardiac catheterization or exercise thallium-201 scintigraphy. Radionuclide angiograms were recorded at rest and immediately before and after RDLBBB in the test group, and at rest and during intermediate and maximal exercise in the control group. The development of RDLBBB was associated with an abrupt decrease in left ventricular ejection fraction (LVEF) in six of seven patients (mean decrease 6 +/- 5%) and no overall increase in LVEF between rest and maximal exercise (65 +/- 9% and 65 +/- 12%, respectively). In contrast, LVEF in the control group was 62 +/- 8% at rest and increased to 72 +/- 8% at intermediate and 78 +/- 7% at maximal exercise. The onset of RDLBBB was associated with the development of asynchronous left ventricular contraction in each patient and hypokinesis in four of seven patients. All patients in themore » control group had normal wall motion at rest and exercise. These data indicate that the development of RDLBBB is associated with changes in global and regional ventricular function that may be confused with development of left ventricular ischemia during exercise.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Department of Medicine, Cardiovascular Division, Duke University Medical Center, Durham, North Carolina
OSTI Identifier:
5764606
Resource Type:
Journal Article
Resource Relation:
Journal Name: Circulation; (United States); Journal Volume: 67:5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR DISEASES; DIAGNOSTIC TECHNIQUES; HEART; BIOMEDICAL RADIOGRAPHY; DYNAMIC FUNCTION STUDIES; SCINTISCANNING; EXERCISE; PATIENTS; THALLIUM 201; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Bramlet, D.A., Morris, K.G., Coleman, R.E., Albert, D., and Cobb, F.R. Effect of rate-dependent left bundle branch block on global and regional left ventricular function. United States: N. p., 1983. Web. doi:10.1161/01.CIR.67.5.1059.
Bramlet, D.A., Morris, K.G., Coleman, R.E., Albert, D., & Cobb, F.R. Effect of rate-dependent left bundle branch block on global and regional left ventricular function. United States. doi:10.1161/01.CIR.67.5.1059.
Bramlet, D.A., Morris, K.G., Coleman, R.E., Albert, D., and Cobb, F.R. Sun . "Effect of rate-dependent left bundle branch block on global and regional left ventricular function". United States. doi:10.1161/01.CIR.67.5.1059.
@article{osti_5764606,
title = {Effect of rate-dependent left bundle branch block on global and regional left ventricular function},
author = {Bramlet, D.A. and Morris, K.G. and Coleman, R.E. and Albert, D. and Cobb, F.R.},
abstractNote = {Seven subjects with rate-dependent left bundle branch block (RDLBBB) and 13 subjects with normal conduction (control group) underwent upright bicycle exercise radionuclide angiography to determine the effects of the development of RDLBBB on global and regional left ventricular function. Six of the seven subjects with RDLBBB had atypical chest pain syndromes; none had evidence of cardiac disease based on clinical examination and either normal cardiac catheterization or exercise thallium-201 scintigraphy. Radionuclide angiograms were recorded at rest and immediately before and after RDLBBB in the test group, and at rest and during intermediate and maximal exercise in the control group. The development of RDLBBB was associated with an abrupt decrease in left ventricular ejection fraction (LVEF) in six of seven patients (mean decrease 6 +/- 5%) and no overall increase in LVEF between rest and maximal exercise (65 +/- 9% and 65 +/- 12%, respectively). In contrast, LVEF in the control group was 62 +/- 8% at rest and increased to 72 +/- 8% at intermediate and 78 +/- 7% at maximal exercise. The onset of RDLBBB was associated with the development of asynchronous left ventricular contraction in each patient and hypokinesis in four of seven patients. All patients in the control group had normal wall motion at rest and exercise. These data indicate that the development of RDLBBB is associated with changes in global and regional ventricular function that may be confused with development of left ventricular ischemia during exercise.},
doi = {10.1161/01.CIR.67.5.1059},
journal = {Circulation; (United States)},
number = ,
volume = 67:5,
place = {United States},
year = {Sun May 01 00:00:00 EDT 1983},
month = {Sun May 01 00:00:00 EDT 1983}
}