Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Infect. Immun.; (United States)

OSTI ID:5762339

Suzuki, Y; Kobayashi, A

In the acute phase of Toxoplasma infection, the function of both helper T and B cells was suppressed in primary antibody responses to dinitrophenol (DNP)-conjugated protein antigens. During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen. Plastic-adherent cells from the spleens of Toxoplasma-infected and X-irradiated (400 rads) mice had strong suppressor activity in primary anti-sheep erythrocyte antibody responses of normal mouse spleen cells in vitro. These data suggest that the activation of irradiation-resistant and plastic-adherent suppressor cells causes the suppression of both T and B cells in Toxoplasma-infected mice.

• Research Organization: Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan
• OSTI ID: 5762339
• Journal Information: Infect. Immun.; (United States), Vol. 40:1
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIAL DISEASES
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IMMUNOSUPPRESSION
ANTIBODIES
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560152* - Radiation Effects on Animals- Animals