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Title: Does the oral zinc tolerance test measure zinc absorption

Abstract

Increases in plasma zinc concentration were compared with radiozinc absorption after oral test doses. Ten healthy, fasting subjects were each given 385 mumol zinc chloride (25 mg Zn) labelled with 0.5 muCi /sup 65/ZnCl/sub 2/ and a non-absorbed marker, /sup 51/CrCl/sub 3/, dissolved in 100 ml of water; another 10 persons were given 354 mumol zinc chloride and 125 g of minced turkey containing 31 mumol zinc also labelled with /sup 65/Zn and /sup 51/Cr. Measurements were made of plasma zinc concentration at hourly intervals for 5 hours, radiozinc absorption by stool counting of unabsorbed radioactivity 12-36 hours later, and radiozinc retention by whole body counting at 7 days. The mean percentage of radiozinc absorbed and retained in the body from the two test meals was found to be identical (42%). In contrast the increased area under the plasma zinc curve up to 5 hours after the turkey meal, 28 +/- 9 mumol/L (mean +/- SD) was significantly less than that for zinc chloride alone, 47 +/- 15 mumol/L, p less than 0.005. Despite this difference, a good correlation was found between the area under the plasma zinc curve and /sup 65/Zn absorption in individual subjects after each meal. Themore » discrepancy between the results of zinc absorption derived from the plasma zinc curve and /sup 65/Zn absorption for the liquid and solid test meals was most likely explained by binding of zinc to food and delayed gastric emptying of the solid meal. With a test meal of turkey meat at least this dampened the plasma appearance of zinc but did not affect its overall absorption.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. Hospital, London, Ontario
OSTI Identifier:
5741771
Resource Type:
Journal Article
Journal Name:
Am. J. Clin. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 41:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ZINC; INTESTINAL ABSORPTION; RETENTION; BLOOD PLASMA; CHEMICAL BONDS; CHROMIUM 51; COMPARATIVE EVALUATIONS; EXCRETION; FECES; FOOD; LABELLED COMPOUNDS; ORAL ADMINISTRATION; TRACER TECHNIQUES; TURKEY; WHOLE-BODY COUNTING; ZINC 65; ABSORPTION; ASIA; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY FLUIDS; CHROMIUM ISOTOPES; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DEVELOPING COUNTRIES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; METALS; MIDDLE EAST; NUCLEI; RADIOISOTOPES; UPTAKE; WASTES; ZINC ISOTOPES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Valberg, L S, Flanagan, P R, Brennan, J, and Chamberlain, M J. Does the oral zinc tolerance test measure zinc absorption. United States: N. p., 1985. Web.
Valberg, L S, Flanagan, P R, Brennan, J, & Chamberlain, M J. Does the oral zinc tolerance test measure zinc absorption. United States.
Valberg, L S, Flanagan, P R, Brennan, J, and Chamberlain, M J. Tue . "Does the oral zinc tolerance test measure zinc absorption". United States.
@article{osti_5741771,
title = {Does the oral zinc tolerance test measure zinc absorption},
author = {Valberg, L S and Flanagan, P R and Brennan, J and Chamberlain, M J},
abstractNote = {Increases in plasma zinc concentration were compared with radiozinc absorption after oral test doses. Ten healthy, fasting subjects were each given 385 mumol zinc chloride (25 mg Zn) labelled with 0.5 muCi /sup 65/ZnCl/sub 2/ and a non-absorbed marker, /sup 51/CrCl/sub 3/, dissolved in 100 ml of water; another 10 persons were given 354 mumol zinc chloride and 125 g of minced turkey containing 31 mumol zinc also labelled with /sup 65/Zn and /sup 51/Cr. Measurements were made of plasma zinc concentration at hourly intervals for 5 hours, radiozinc absorption by stool counting of unabsorbed radioactivity 12-36 hours later, and radiozinc retention by whole body counting at 7 days. The mean percentage of radiozinc absorbed and retained in the body from the two test meals was found to be identical (42%). In contrast the increased area under the plasma zinc curve up to 5 hours after the turkey meal, 28 +/- 9 mumol/L (mean +/- SD) was significantly less than that for zinc chloride alone, 47 +/- 15 mumol/L, p less than 0.005. Despite this difference, a good correlation was found between the area under the plasma zinc curve and /sup 65/Zn absorption in individual subjects after each meal. The discrepancy between the results of zinc absorption derived from the plasma zinc curve and /sup 65/Zn absorption for the liquid and solid test meals was most likely explained by binding of zinc to food and delayed gastric emptying of the solid meal. With a test meal of turkey meat at least this dampened the plasma appearance of zinc but did not affect its overall absorption.},
doi = {},
journal = {Am. J. Clin. Nutr.; (United States)},
number = ,
volume = 41:1,
place = {United States},
year = {1985},
month = {1}
}