Effects of polychlorinated biphenyls and nutritional restriction on barbituate-induced sleeping times and selected blood characteristics in raccoons (Procyon lotor)
Hepatic microsomal enzyme activity was induced in wild-trapped raccoons (Procyon lotor) and selected blood characteristics were measured in an effort to detect responses due to PCB ingestion, nutritional restriction, and their interactions. Barbiturate-induced sleeping times were used as an index of hepatic microsomal activity because they have been used reliably by other workers. Blood characteristics examined in the study were nonesterified fatty acids (NEFA), cholesterol, and three ketone bodies (D-(-)-3-hydroxybutyrate, acetoacetate, and acetone). Results show a reduction in sleeping times, elevated NEFA and D-(-)-3-hydroxybutyrate concentrations, and lower cholesterol concentrations in PCB-treated groups. A highly significant interaction between PCB treatment and nutritional restriction was observed in acetoacetate concentrations. (JMT)
- Research Organization:
- Virginia Polytechnic Inst. and State Univ., Blacksburg
- OSTI ID:
- 5740038
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 28:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BARBITURATES
BIOLOGICAL EFFECTS
CHLORINATED AROMATIC HYDROCARBONS
DIET
BEHAVIOR
BLOOD
BLOOD CHEMISTRY
CARBOXYLIC ACIDS
CHOLESTEROL
ENZYME ACTIVITY
KETONES
NUTRITION
RESPONSE MODIFYING FACTORS
SLEEP
WILD ANIMALS
ANESTHETICS
AROMATICS
AZINES
BIOLOGICAL MATERIALS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
HYPNOTICS AND SEDATIVES
MATERIALS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PYRIMIDINES
STEROIDS
STEROLS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)