Inhibition of ultraviolet-induced carcinogenesis by all-trans retinoic acid

Journal Article · Sun Mar 01 00:00:00 EST 1981 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12525686· OSTI ID:5732688

Epstein, J H; Grekin, D A

The effects of all-trans retinoic acid (RA) in 0.05%, 0.025% and 0.005% concentrations on ultraviolet (UV) induced carcinogenesis was investigated in the skin of Uscd strain hairless mice. A carcinogenic amount of UV energy was delivered over the 12-mo period of the study. The 0.025% and 0.005% RA solutions did not alter the development of cutaneous cancers. However, the 0.05% RA concentration significantly inhibited the tumor formation in this study.

• OSTI ID: 5732688
• Journal Information: J. Invest. Dermatol.; (United States), Vol. 76:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SKIN
BIOLOGICAL RADIATION EFFECTS
VITAMIN A
RADIOSENSITIVITY EFFECTS
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
MICE
NEOPLASMS
RADIOINDUCTION
ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
MAMMALS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
VITAMINS
560152* - Radiation Effects on Animals- Animals