Intravenous elimination and percutaneous absorption of topically applied melphalan-14C (NSC-8806) in Yorkshire white pigs. Final report, 17 August-1 December 1977

Technical Report · Tue Mar 28 00:00:00 EST 1978

OSTI ID:5731823

Skierkowski, P; Murphy, J C; Watson, E S; Folk, R M; Pavkov, K L

The distribution and elimination of intravenously administered Melphalan-14C (NSC-8806) was studied in female, weanling Yorkshire white pigs. A three compartment pharmacokinetic model is indicated with a very slow elimination phase (half life = 214 hours). Assay of tissue samples indicate bone and fat may be acting as depots for the drug. After 8 days an average of 70% was eliminated via the urine. Percutaneous studies showed an average of 4.02% of the applied dose was absorbed after 14 days. Significant levels of radioactivity were also detected in skin surrounding the site of application.

• Research Organization: Battelle Columbus Toxicology Program Office, McLean, VA (USA); Mississippi Univ., University (USA). Research Inst. of Pharmaceutical Sciences
• DOE Contract Number: N01-CM-4-3746
• OSTI ID: 5731823
• Report Number(s): PB-290436; TRN: 80-001337
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
SKIN ABSORPTION
TISSUE DISTRIBUTION
CARBON 14 COMPOUNDS
EXCRETION
INTRAVENOUS INJECTION
SWINE
TRACER TECHNIQUES
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DISTRIBUTION
DOMESTIC ANIMALS
DRUGS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
UPTAKE
VERTEBRATES
WASTES
551001* - Physiological Systems- Tracer Techniques
550600 - Medicine