Stereoselective intramolecular cyclization in irradiated nucleic acids: R- and S-8,5'-cycloadenosine in polyadenylic acid

Journal Article · Wed Jan 29 00:00:00 EST 1986 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/S0006-291X(86)80502-2· OSTI ID:5731582

Fuciarelli, A F; Shum, F Y; Raleigh, J A

The yields of R- and S-8,5'-cycloadenosines have been measured in poly A irradiated with gamma rays in the absence of oxygen. High performance liquid chromatographic analysis of the nucleoside analogues obtained by hydrolysis of the irradiated poly A shows that the R isomer predominates to the extent of 2.5-fold at doses of ionizing radiation in the range of 0-400 Gy.

• Research Organization: Cross Cancer Institute, Edmonton, Alberta, Canada
• OSTI ID: 5731582
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOSINE
CHEMICAL RADIATION EFFECTS
DEHYDROCYCLIZATION
GAMMA RADIATION
HYDROLYSIS
ISOMERS
LIQUID COLUMN CHROMATOGRAPHY
NUCLEIC ACIDS
NUCLEOSIDES
CHEMICAL REACTIONS
CHEMISTRY
CHROMATOGRAPHY
DECOMPOSITION
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
LYSIS
NUCLEOTIDES
ORGANIC COMPOUNDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RIBOSIDES
SEPARATION PROCESSES
SOLVOLYSIS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)